Clinical experiment designed to assess clinical efficacy targeting N/A in human patients. Primary outcome: feasibility (retention rate) and inflammatory biomarkers
This single-arm pre-post pilot study evaluated the feasibility and preliminary effects of a Mediterranean diet self-monitoring mobile application (Olitor) in patients with symptomatic paroxysmal atrial fibrillation. Participants used the app for 3 months, which prompted weekly diet tracking and provided tailored feedback based on Mediterranean diet principles. The study assessed multiple outcomes including inflammatory biomarkers (interleukin-6 and C-reactive protein), atrial fibrillation symptoms, quality of life measures, physical activity levels, diet knowledge, self-efficacy, and body mass index. The intervention aimed to reduce inflammation through dietary modification, potentially improving symptom burden and quality of life in AF patients. Results showed promising trends with reductions in inflammatory markers, improvements in quality of life (particularly in the family QoL subdomain with large effect size), increased walking activity, and gains in self-efficacy and diet knowledge. The study demonstrated good retention rates and feasibility of the digital health intervention approach.
3-month single-arm pre-post pilot study using Olitor Mediterranean diet app with weekly diet tracking and tailored feedback, measuring outcomes at baseline and 3 months
Reduced inflammation, improved AF symptoms and quality of life through Mediterranean diet adherence
Good retention rates, reductions in inflammatory markers, improvements in quality of life measures
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