An evolutionary perspective on cell migration: Digging for the roots of amoeboid motility.

Fritz-Laylin et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201701074) take advantage of the deep knowledge of mechanisms of actin-based motility and a growing number of sequenced genomes across the tree of life to gain insight into the machinery needed for pseudopod-based amoeboid motility and how it evolved.