The function and regulation of TET2 in innate immunity and inflammation.

1. Protein Cell. 2021 Mar;12(3):165-173. doi: 10.1007/s13238-020-00796-6. Epub 2020 Oct 21. The function and regulation of TET2 in innate immunity and inflammation. Cong B(1), Zhang Q(2), Cao X(3)(4)(5). Author information: (1)Laboratory of Immunity and Inflammation, College of Life Sciences, Nankai University, Tianjin, 300071, China. (2)National Key Laboratory of Medical Immunology, Institute of Immunology, Navy Military Medical University, Shanghai, 200433, China. (3)Laboratory of Immunity and Inflammation, College of Life Sciences, Nankai University, Tianjin, 300071, China. caoxt@immunol.org. (4)National Key Laboratory of Medical Immunology, Institute of Immunology, Navy Military Medical University, Shanghai, 200433, China. caoxt@immunol.org. (5)Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, 100005, China. caoxt@immunol.org. TET2, a member of ten-eleven translocation (TET) family as α-ketoglutarate- and Fe2+-dependent dioxygenase catalyzing the iterative oxidation of 5-methylcytosine (5mC), has been widely recognized to be an important regulator for normal hematopoiesis especially myelopoiesis. Mutation and dysregulation of TET2 contribute to the development of multiple hematological malignancies. Recent studies reveal that TET2 also plays an important role in innate immune homeostasis by promoting DNA demethylation or independent of its enzymatic activity. Here, we focus on the functions of TET2 in the initiation and resolution of inflammation through epigenetic regulation and signaling network. In addition, we highlight regulation of TET2 at various molecular levels as well as the correlated inflammatory diseases, which will provide the insight to intervene in the pathological process caused by TET2 dysregulation. DOI: 10.1007/s13238-020-00796-6 PMCID: PMC7895883 PMID: 33085059 [Indexed for MEDLINE]