Nutraceutical based SIRT3 activators as therapeutic targets in Alzheimer's disease.

1. Neurochem Int. 2021 Mar;144:104958. doi: 10.1016/j.neuint.2021.104958. Epub 2021 Jan 12. Nutraceutical based SIRT3 activators as therapeutic targets in Alzheimer's disease. Govindarajulu M(1), Ramesh S(1), Neel L(1), Fabbrini M(1), Buabeid M(2), Fujihashi A(1), Dwyer D(1), Lynd T(1), Shah K(3), Mohanakumar KP(4), Smith F(1), Moore T(1), Dhanasekaran M(5). Author information: (1)Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, AL 36849, USA. (2)Clinical Pharmacy Department, College of Pharmacy and Health Sciences, Ajman University, United Arab Emirates. (3)Department of Ophthalmology, D.Y. Patil Medical College and Research Hospital, Mumbai, India. (4)Inter University Centre for Biomedical Research & Super Specialty Hospital, Kottayam, India. (5)Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, AL 36849, USA. Electronic address: dhanamu@auburn.edu. Alzheimer's disease (AD) is the most common neurodegenerative disease, and its incidence is increasing worldwide with increased lifespan. Currently, there is no effective treatment to cure or prevent the progression of AD, which indicates the need to develop novel therapeutic targets and agents. Sirtuins, especially SIRT3, a mitochondrial deacetylase, are NAD-dependent histone deacetylases involved in aging and longevity. Accumulating evidence indicates that SIRT3 dysfunction is strongly associated with pathologies of AD, hence, therapeutic modulation of SIRT3 activity may be a novel application to ameliorate the pathologies of AD. Natural products commonly used in traditional medicine have wide utility and appear to have therapeutic benefits for the treatment of neurodegenerative diseases such as AD. The present review summarizes the currently available natural SIRT3 activators and their potentially neuroprotective molecular mechanisms of action that make them a promising agent in the treatment and managem