Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy through SIRT3-mediated TFAM deacetylation.

Deng Z, He M, Hu H, Zhang W, Zhang Y, Ge Y, Ma T, Wu J, Li L, Sun M

Autophagy 2024

1. Autophagy. 2024 Jan;20(1):151-165. doi: 10.1080/15548627.2023.2252265. Epub 2023 Aug 31. Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy through SIRT3-mediated TFAM deacetylation. Deng Z(1)(2), He M(1)(2), Hu H(1), Zhang W(1)(2), Zhang Y(1), Ge Y(1)(3), Ma T(1), Wu J(1), Li L(1), Sun M(1)(2), An S(1)(2), Li J(1), Huang Q(1)(2), Gong S(1)(4), Zhang J(1)(5), Chen Z(1), Zeng Z(1)(2). Author information: (1)Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China. (2)Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China. (3)School of Nursing, Southern Medical University, Guangzhou, Guangdong, China. (4)School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China. (5)The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China. AKI: acute kidney injury; ATP: adenosine triphosphate; BUN: blood urea nitrogen; CLP: cecal ligation and puncture; eGFR: estimated glomerular filtration rate; H&E: hematoxylin and eosin staining; LCN2/NGAL: lipocalin 2; LPS: lipopolysaccharide; LTL: lotus tetragonolobus lectin; mKeima: mitochondria-targeted Keima; mtDNA: mitochondrial DNA; PAS: periodic acid - Schiff staining; RTECs: renal tubular epithelial cells; SAKI: sepsis-induced acute kidney injury; Scr: serum creatinine; SIRT3: sirtuin 3; TFAM: transcription factor A, mitochondrial; TMRE: tetramethylrhodamine. DOI: 10.1080/15548627.2023.2252265 PMCID: PMC10761103 PMID: 37651673 [Indexed for MEDLINE] Conflict of interest statement: No potential conflict of interest was reported by the author(s).