NAD(+) rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis.

1. Neuron. 2023 Nov 15;111(22):3634-3649.e7. doi: 10.1016/j.neuron.2023.08.010. Epub 2023 Sep 7. NAD(+) rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis. Zhan R(1), Meng X(2), Tian D(3), Xu J(2), Cui H(4), Yang J(2), Xu Y(5), Shi M(2), Xue J(2), Yu W(6), Hu G(5), Li K(2), Ge X(7), Zhang Q(5), Zhao M(4), Du J(8), Guo X(4), Xu W(8), Gao Y(8), Yao C(9), Chen F(10), Chen Y(5), Shan W(5), Zhu Y(5), Ji L(5), Pan B(5), Yu Y(11), Li W(12), Zhao X(5), He Q(13), Liu X(14), Huang Y(2), Liao S(15), Zhou B(16), Chui D(17), Chen YE(18), Sun Z(19), Dong E(20), Wang Y(21), Zheng L(22). Author information: (1)The Institute of Cardiovascular Sciences, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, Peking University, Beijing 100191, China; Research Center for Cardiopulmonary Rehabilitation, University of Health and Rehabilitation Sciences Qingdao Hospital (Qingdao Municipal Hospital), School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao 266071, China. (2)Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, The Capital Medical University, Beijing, China. (3)Department of Pathology, Medical College, Shantou University, Shantou, China. (4)Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China. (5)The Institute of Cardiovascular Sciences, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, Peking University, Beijing 100191, China. (6)Peking University Shenzhen Hospital, Beijing, China. (7)Beijing Institute Brain Disorders, Capital Medical University, Beijing, China. (8)Research Center for Cardiopulmonary Rehabilitation, University of Health and Rehabilitation Sciences Qingdao Hospital (Qingdao Municipal Hospital), School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao 266071, China. (9)Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. (10)Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. (11)Chinese Institute of Rehabilitation Science, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China. (12)Institute of Genetics and Development Biology, Chinese Academy of Sciences, Beijing, China. (13)Center of Medical and Health Analysis, Peking University, Beijing, China. (14)National Protein Science Technology Center, Tsinghua University, Beijing, China. (15)Department of Clinical Medical Research Center, Guangdong Provincial Engineering Research Center of Autoimmune Disease Precision Medicine, The Second Clinical Medical College, Jinan University, Shenzhen People's Hospital, Shenzhen, China. (16)State Key Laboratory of Cell Biology, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. (17)Beijing Key Laboratory of Magnetic Resonance Imaging Devices and Technology and Department of Neurology, Peking University Third Hospital, Beijing, China. (18)Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, USA. (19)Department of Medicine and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA. (20)The Institute of Cardiovascular Sciences, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, Peking University, Beijing 100191, China; Research Center for Cardiopulmonary Rehabilitation, University of Health and Rehabilitation Sciences Qingdao Hospital (Qingdao Municipal Hospital), School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao 266071, China; Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China; Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases, Chinese Academy of Medical Sciences, Haihe Laboratory of Cell Ecosystem, Beijing, China. Electronic address: donged@bjmu.edu.cn. (21)Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced