Microbiome-derived indole-3-lactic acid reduces amyloidopathy through aryl-hydrocarbon receptor activation.
1. Brain Behav Immun. 2024 Nov;122:568-582. doi: 10.1016/j.bbi.2024.08.051. Epub 2024 Aug 27. Microbiome-derived indole-3-lactic acid reduces amyloidopathy through aryl-hydrocarbon receptor activation. Kim H(1), Lee E(1), Park M(1), Min K(1), Diep YN(2), Kim J(1), Ahn H(1), Lee E(1), Kim S(1), Kim Y(1), Kang YJ(3), Jung JH(4), Byun MS(5), Joo Y(1), Jeong C(1), Lee DY(6), Cho H(2), Park H(7), Kim T(8). Author information: (1)Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea. (2)Institute of Quantum Biophysics, Sungkyunkwan University, Suwon, Gyeonggi, Republic of Korea; Department of Biophysics, Sungkyunkwan University, Suwon, Gyeonggi, Republic of Korea; Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Gyeonggi, Republic of Korea. (3)Institute of Quantum Biophysics, Sungkyunkwan University, Suwon, Gyeonggi, Republic of Korea; Department of Biophysics, Sungkyunkwan University, Suwon, Gyeonggi, Republic of Korea. (4)Department of Psychiatry, Chungbuk National University Hospital, Cheongju, Republic of Korea. (5)Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea. (6)Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea; Institute of Human Behavioral Medicine, Medical Research Center Seoul National University, Seoul, Republic of Korea. (7)Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea; Genome and Company, Gyeonggi-do, Republic of Korea. Electronic address: hspark27@gist.ac.kr. (8)Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIS