Tubule-Specific Compensatory Responses to Cpt1a Deletion in Aged Mice.

KEY POINTS: Aging plus high fat diet suppresses expression of genes related to metabolism and fatty acid oxidation in the proximal tubules. Proximal tubules lacking BACKGROUND: Fatty acid oxidation (FAO) is the preferred energy pathway in the proximal tubule (PT), and carnitine palmitoyltransferase 1A ( METHODS: RESULTS: HFD-aged mice had increased fibrosis, inflammation, and more injured PT cells than young mice. Whereas PT segments from HFD-aged mice had significant transcriptional changes in metabolism-related pathways, the DCT had more changes in inflammation-related pathways. Compared with floxed mice, HFD-aged CONCLUSIONS: The upregulated