Miro1: A potential target for treating neurological disorders.

1. Neuroscience. 2025 Jun 21;577:228-239. doi: 10.1016/j.neuroscience.2025.05.019. Epub 2025 May 20. Miro1: A potential target for treating neurological disorders. Zeng L(1), Yang J(2), Zhang C(3), Zhu J(4), Zhong S(5), Liu X(6), Xie H(7), Wang L(8), Chen L(9), Zhong M(10), Hua F(11), Liang W(12). Author information: (1)Anesthesia Surgery Center, The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China; Gannan Medical University, Ganzhou 341000 Jiangxi, PR China. Electronic address: zlh1101473695@163.com. (2)Academic Affairs Department, The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China. Electronic address: 505373510@qq.com. (3)Gannan Medical University, Ganzhou 341000 Jiangxi, PR China. Electronic address: 15935135760@163.com. (4)Gannan Medical University, Ganzhou 341000 Jiangxi, PR China. Electronic address: zhujunjie13141516@163.com. (5)Department of Anesthesiology, Longnan First People's Hospital, Ganzhou 341000 Jiangxi, PR China. Electronic address: 41499529@qq.com. (6)Anesthesia Surgery Center, The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China. Electronic address: liuxingmed@163.com. (7)Anesthesia Surgery Center, The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China. Electronic address: gyfyxhy@163.com. (8)Anesthesia Surgery Center, The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China. Electronic address: wwwwanglifeng@126.com. (9)Anesthesia Surgery Center, The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China. Electronic address: zgx8778@126.com. (10)Anesthesia Surgery Center, The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China. Electronic address: zml8802@163.com. (11)Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, 1# Minde Road, Nanchang 330006 Jiangxi, PR China. Electronic address: huafuzhou@126.com. (12)Anesthesia Surgery Center, The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China; Gannan Medical University, Ganzhou 341000 Jiangxi, PR China. Electronic address: lwd0929@gmu.edu.cn. The Miro1 protein is a member of the mitochondrial Rho GTPase (Miro) protein family and plays a crucial role in regulating the dynamic processes of mitochondria and participating in cellular movement and mitochondrial transport. In the nervous system, it ensures adequate energy supply for normal neuronal function and synaptic transmission. Additionally, Miro1 actively participates in the regulation of mitochondrial quality control and stress responses within neurons. Its primary function is to sense intracellular stress signals to regulate mitochondrial movement and metabolism, thereby adapting to environmental changes. Multiple studies have indicated that the Miro1 protein is associated with the pathogenesis of various neurological disorders, such as Alzheimer's Disease(AD), Parkinson's Disease(PD), and Amyotrophic Lateral Sclerosis(ALS). This article reviews the mechanistic role of Miro1 in these diseases and summarizes the latest research on its involvement in neurological disorders. These efforts aim to provide unified treatment strategies for certain neurological disorders and explore the potential for treating complex neurological diseases. Copyright © 2025 The Author(s). Published by Elsevier Inc. All rights reserved. DOI: 10.1016/j.neuroscience.2025.05.019 PMID: 40403957 [Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.