mechanism 2,522 words KG: ent-gene-7b80a607 2026-04-01
kind:mechanismsection:mechanismsstate:publishedevidence:strong
Contents

mTOR Signaling in Autophagy and Lysosomal Function

🔬 Protein Info
Gene Symbolent-gene-7b80a607
ULK1Phosphorylation inhibits ULK1 complex formation, blocking autophagy initiation
TFEBPhosphorylation retains TFEB in cytoplasm, repressing lysosomal biogenesis genes
VPS34/PIK3C3Inhibition reduces PI3P production needed for phagophore formation
ATG14LSuppresses autophagosome-lysosome fusion
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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