| Gene Symbol | CALCINEURINB |
| Aliases | CALCINEURINBPROTEIN |
| Function | Calcineurin (CN) is a calcium/calmodulin-dependent serine/threonine phosphatase that plays a critical role in cellular signaling in the brain. |
| GeneCards | CALCINEURINB |
| Human Protein Atlas | CALCINEURINB |
| Direct interaction | Aβ oligomers can bind to neuronal membranes and alter calcium channel function, causing pathological calcium influx |
| NMDA receptor dysregulation | Aβ promotes excessive NMDA receptor activation, leading to calcium overload |
| Calcium homeostasis disruption | Aβ impairs mitochondria and endoplasmic reticulum calcium stores |
| Direct dephosphorylation | Calcineurin can dephosphorylate tau at several pathological sites including Ser202, Thr205, and Ser396 |
| Kinase activation | Chronic calcineurin activation can lead to activation of tau kinases through transcription-dependent mechanisms |
| GSK-3β regulation | Calcineurin can modulate GSK-3β activity, a major tau kinase, through intermediate signaling pathways |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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