| Gene Symbol | RPL36A |
| Aliases | RPL36APROTEIN |
| Chromosome | 9q21.11 |
| Function | RPL36A encodes a ribosomal protein that is a component of the 60S subunit. |
| Primary Expression | most tissues with high expression in brain |
| Subcellular Localization | </th><td>Cytoplasm, ribosome</td></tr> |
| Ensembl ID | ENSG00000256039 |
| GeneCards | RPL36A |
| Human Protein Atlas | RPL36A |
| Basic residues | RPL36A contains multiple lysine and arginine residues that facilitate binding to the 28S rRNA of the 60S subunit |
| Interface localization | The protein is positioned at the interface between the large and small ribosomal subunits, where it participates in the conformational changes required for translation |
| tRNA interaction sites | RPL36A contributes to stabilizing the binding of tRNA molecules at the A-site, P-site, and E-site of the ribosome |
| tRNA stabilization | RPL36A helps stabilize the binding of tRNA molecules at the ribosomal sites, ensuring accurate codon-anticodon pairing |
| Translocation | The protein participates in the translocation step, where the ribosome moves along the mRNA, shifting tRNA molecules from the A-site to the P-site and from the P-site to the E-site |
| Synaptic plasticity | Local protein synthesis at synapses is required for long-term potentiation (LTP) and memory formation. Ribosomal proteins, including RPL36A, contribute to this process |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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