Contents

Quality of Life in Corticobasal Syndrome

Disease Info

Motor impairment	Asymmetric rigidity, bradykinesia, dystonia, and myoclonus severely limit daily activities
Mobility	Progressive gait disturbance leads to falls, dependence on assistive devices, and eventual wheelchair use
Self-care	Dressing, grooming, bathing, and feeding become increasingly difficult
Communication	Speech and voice changes impact daily conversations and social interactions
Depression	Prevalence of clinically significant depression ranges from 30-50%
Anxiety	Related to disease progression, functional decline, and uncertainty about the future
Apathy	Common in CBS, often mistaken for depression
Frustration and grief	Loss of independence and identity as disease progresses
Social isolation	Progressive disability limits ability to participate in social activities
Role changes	Patients transition from caregivers or breadwinners to care recipients
Relationship strain	Family and friend relationships often become strained
Work disability	Most patients must stop working within 2-3 years of diagnosis
Databases	OMIM Orphanet ClinicalTrials PubMed

Knowledge Graph