disease 1,306 words KG: ent-dise-1085a2cb
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Voice and Speech in Corticobasal Syndrome

Disease Info
Articulatory errorsInconsistent phonemic distortions, particularly affecting consonant clusters
Groping behaviorVisible searching movements of the lips, tongue, and jaw during speech initiation
Sound substitutionsPhonemic paraphasias (e.g., "table" → "cable")
Prolonged phonemesAbnormal prolongation of consonant sounds
Repeated attemptsMultiple attempts at self-correction
Reduced speech rateOverall slowing of articulation[@johns2023][@du2022]
Premotor cortex (BA6)Damage to lateral premotor regions involved in speech motor planning
Supplementary motor area (SMA)Disruption of sequential speech movements
Left hemisphere predominanceAOS in CBS typically reflects left hemisphere cortical pathology
Reduced vocal loudnessHypophonia, often asymmetric (more affected on the side of motor symptoms)
MonopitchDecreased pitch variation
MonotoneFlat intonation patterns
DatabasesOMIMOrphanetClinicalTrialsPubMed

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