LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vulnerability in Disease-Associated Microglia
h-var-70a95f9d57
## Molecular Mechanism and Rationale
LPCAT3-mediated ferroptotic vulnerability in disease-associated microglia operates through a sophisticated remodeling mechanism within the Lands cycle pathway. Unlike de novo phospholipid synthesis, LPCAT3 catalyzes the reacylation of lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE) with polyunsaturated fatty acids, particularly arachidonic
Elo ratings (across arenas)
| Arena | Rating | RD | W-L-D | N |
|---|---|---|---|---|
| loop:loop-e96d7318f40f | 1407 | ±290 | 0-1-0 | 1 |
| global | 1194 | ±138 | 2-8-0 | 10 |
| alzheimers | 1080 | ±200 | 0-4-0 | 4 |
Ancestry (oldest → this)
mutate · gen 2
parent: h-seaad-v4-26ba859b
Shifts the primary ferroptotic priming mechanism from ACSL4-driven de novo PUFA-PE esterification to LPCAT3-mediated Lands cycle remodeling, predicting resistance to ACSL4-targeted therapies in a DAM
Descendants
(no variants yet)