ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes Underlies White Matter Degeneration in Alzheimer's Disease
h-var-f96e38ec20
## Molecular Mechanism and Rationale
ACSL4 (Acyl-CoA Synthetase Long Chain Family Member 4) catalyzes the ATP-dependent esterification of arachidonic acid (AA) and other long-chain polyunsaturated fatty acids (PUFAs) into phosphatidylethanolamine (PE) and phosphatidylserine pools, creating lipid peroxidation substrates essential for ferroptosis execution. In disease-associated oligodendrocytes (D
Elo ratings (across arenas)
| Arena | Rating | RD | W-L-D | N |
|---|---|---|---|---|
| alzheimers | 1252 | ±210 | 1-3-0 | 4 |
Ancestry (oldest → this)
mutate · gen 2
parent: h-seaad-v4-26ba859b
Shifts the cellular scope from disease-associated microglia (DAM) to disease-associated oligodendrocytes (DAO), repositioning ACSL4-driven ferroptotic priming as a mechanism of white matter degenerati
Descendants
(no variants yet)