Immune atlas neuroinflammation analysis in neurodegeneration

Analysis ID: SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402

Domain: Neuroinflammation

Notebook stub generated by recurring CI coverage task.

Research Question

Comprehensive analysis of immune cell subtypes in neurodegeneration: microglia subtypes (DAM, homeostatic, inflammatory), astrocyte reactivity states, T-cell infiltration. Anchor to existing TREM2 (h-b234254c, h-044ee057) and complement cascade hypotheses (h-58e4635a, h-1fe4ba9b, h-5a55aabc). Produce inflammatory pathway diagrams and generate 3-5 new hypotheses connecting immune findings to disease mechanisms.