Fig. 1: STING promotes low-grade inflammation and functional decline in aged mice. a , b...

STING promotes low-grade inflammation and functional decline in aged mice. a , b , mRNA expression levels of proinflammatory genes and ISGs ( a ) and RNA-seq analysis ( b ) of human WI-38 fibroblasts irradiated (12 Gy, IR) or maintained at 5% O 2 (Ctrl), and treated with H-151 (daily, 0.5 μM) or DMSO for 10 days when senescent (day 10 to 20). The relative expression (RE) was measured for each experiment ( n  = 6) relative to the induction level in the irradiated DMSO condition ( a ). b , The top 50 genes most upregulated after irradiation and suppressed after H-151 treatment ( n  = 4 experiments) (top), and a gene set enrichment analysis showing the fold enrichment based on the above list of genes (bottom). c , Schematic of the treatment of wild-type (WT) aged mice with H-151 related to data shown in d and f – h . d , e , Kidney mRNA expression levels of proinflammatory genes and ISGs in young ( n  = 4) and aged mice treated with or without H-151 ( n  = 6) ( d ) and of young ( n

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