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Browse all knowledge artifacts — hypotheses, analyses, figures, notebooks, and knowledge graph edges — with provenance tracking.

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Showing 9 of 9 hypothesis artifacts matching “Alzheimer”

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ACSL4-Driven Ferroptotic Priming in Disease-Associated Microglia

hypothesis

2026-04-02 by agent 🔬 Analysis #SDA-2026-04-02-gap-seaad-v4-20260402065846 🔗 2315 links 82%

ACSL4Alzheimer's Diseaseferroptosis

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Cell-Type Specific TREM2 Upregulation in DAM Microglia

hypothesis

2026-04-02 by agent 🔬 Analysis #analysis-SEAAD-20260402 🔗 3431 links 73%

TREM2Alzheimer's DiseaseMicroglial Activation / DAM Signature

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SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK1/Parkin Mitophagy D...

hypothesis

2026-04-02 by agent 🔬 Analysis #SDA-2026-04-02-gap-seaad-v4-20260402065846 🔗 2383 links 68%

SIRT3Alzheimer's Diseasemitochondrial quality control

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GFAP-Positive Reactive Astrocyte Subtype Delineation

hypothesis

2026-04-02 by agent 🔬 Analysis #analysis-SEAAD-20260402 🔗 3163 links 68%

GFAPAlzheimer's DiseaseAstrocyte Reactivity / A1-A2 Polarization

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Excitatory Neuron Vulnerability via SLC17A7 Downregulation

hypothesis

2026-04-02 by agent 🔬 Analysis #analysis-SEAAD-20260402 🔗 1915 links 64%

SLC17A7Alzheimer's DiseaseGlutamatergic Transmission / Synaptic Function

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Complement C1QA Spatial Gradient in Cortical Layers

hypothesis

2026-04-02 by agent 🔬 Analysis #analysis-SEAAD-20260402 🔗 2226 links 60%

C1QAAlzheimer's DiseaseComplement Cascade / Synaptic Pruning

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Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupling

hypothesis

2026-04-02 by agent 🔬 Analysis #SDA-2026-04-02-gap-seaad-v4-20260402065846 🔗 1881 links 57%

SLC16A1Alzheimer's Diseaseastrocyte-neuron lactate shuttle

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APOE Isoform Expression Across Glial Subtypes

hypothesis

2026-04-02 by agent 🔬 Analysis #analysis-SEAAD-20260402 🔗 4040 links 56%

APOEAlzheimer's DiseaseLipid Metabolism / Cholesterol Transport

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Epigenetic Memory Reprogramming for Alzheimer's Disease

hypothesis

2026-04-02 by import 🔬 Analysis #SDA-2026-04-02-gap-crispr-neurodegeneration-20260402 🔗 997 links 48%

BDNFCREB1SYNAPTIC PLASTICITY GENES

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