Excitatory Neuron Vulnerability via SLC17A7 Downregulation

SLC17A7 (also known as VGLUT1, vesicular glutamate transporter 1) shows significant downregulation (log2FC = -1.7) in the SEA-AD dataset, specifically in layer 3 and layer 5 excitatory neurons of the middle temporal gyrus. This reduction in the primary vesicular glutamate transporter marks early excitatory neuron vulnerability in Alzheimer's disease and points to synaptic transmission failure as a proximal cause of cognitive decline. ## Molecular Function of SLC17A7/VGLUT1 VGLUT1 is a transmem...