Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BRD2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | BRD2 |
| Full Name | Bromodomain-Containing Protein 2 |
| Chromosome | 6p21.3 |
| Function | encodes a BET (Bromodomain and Extra-Terminal domain) family transcriptional regulator that reads acetylated histones and recruits transcriptional machinery to active chromatin. |
| UniProt ID | [P25440](https://www.uniprot.org/uniprot/P25440) |
| Ensembl ID | ENSG00000204256 |
| GeneCards | BRD2 |
| Human Protein Atlas | BRD2 |
| Bromodomain 1 (BD1) | Preferentially binds di-acetylated H4 (H4K5acK12ac), a mark enriched at gene promoters during active transcription |
| Bromodomain 2 (BD2) | Binds acetylated H4K5/K8/K12 with broader specificity, contributing to chromatin association during different transcriptional states |
| ET domain | Mediates protein-protein interactions with transcription factors, including recruitment of the Mediator complex and transcriptional elongation factors |
| SEED domain | BRD2-specific domain that interacts with E2F transcription factors, linking histone acetylation to cell cycle gene expression |
| Transcriptional coactivation | BRD2 bridges acetylated chromatin to the transcriptional machinery, facilitating expression of neural-specific genes including ion channels, neurotransmitter receptors, and synaptic proteins |
| Cell cycle regulation | BRD2 interacts with E2F1/E2F2 to drive expression of cyclins and CDKs required for neural progenitor proliferation; BRD2 heterozygous knockout mice show reduced neural tube cell proliferation |
| GABAergic neuron development | BRD2 is essential for specification and maturation of GABAergic interneurons. BRD2 haploinsufficiency reduces GABAergic neuron density, providing a direct mechanistic link to epilepsy |
| Associated Diseases | ALS |
| Interactions | BRD3, BRD4 |
| KG Connections | 9 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["BRD2"]
N1["ALS"]
N0 -->|"associated with"| N1
N2["BRD3"]
N0 -->|"co expressed with"| N2
N3["BRD4"]
N0 -->|"co expressed with"| N3
N4["neurodegeneration"]
N0 -->|"implicated in"| N4
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 gene
class N3 gene| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| BRD3 | activates | gene | 0.60 |
| BRD4 | activates | gene | 0.60 |
| ALS | associated_with | disease | 0.60 |
| BRD3 | co_expressed_with | gene | 0.50 |
| BRD4 | co_expressed_with | gene | 0.50 |
| benchmark_ot_ad_answer_key:BRD2 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| benchmark_ot_ad_answer_key:BRD2 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||