| Gene Symbol | KDM5C |
| Full Name | Lysine Demethylase 5C |
| Chromosome | Xp11.22 |
| Function | encodes an X-linked JmjC domain-containing histone demethylase that removes di- and trimethyl marks from histone H3 lysine 4 (H3K4me2/3). |
| Amino Acids | 1560 aa |
| Pathways | Epigenetic, epigenetic regulation |
| UniProt ID | [P41229](https://www.uniprot.org/uniprot/P41229) |
| Ensembl ID | ENSG00000126012 |
| GeneCards | KDM5C |
| Human Protein Atlas | KDM5C |
| JmjN + JmjC domains | Catalytic domains for Fe(II)/2-OG-dependent oxidative demethylation of H3K4me2/3 |
| ARID domain | AT-rich interaction domain for DNA binding, directing KDM5C to specific genomic loci |
| PHD fingers (2x) | PHD1 reads H3K9me3, linking KDM5C to heterochromatin; PHD2 reads unmethylated H3K4, providing product recognition |
| C5HC2 zinc finger | Mediates interactions with transcriptional co-repressors including REST/NRSF and HDAC complexes |
| Enhancer decommissioning | KDM5C removes H3K4me3 from deactivating enhancers, converting them to poised (H3K4me1) state. Loss of KDM5C causes persistent "ghost" enhancers that drive spurious gene expression |
| Associated Diseases | neurodegeneration |
| Interactions | MYC, EGFR, ERK1, TERT, GABPA, CANCER |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |