Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DARS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | DARS1 |
| Full Name | Aspartyl-tRNA Synthetase 1 |
| Chromosome | 2q21.3 |
| Function | encodes a 643 amino acid protein with a molecular weight of approximately 71 kDa. |
| Subcellular Localization | DARS1 localizes to cytoplasm (primary location), nucleus (observed in some cell types), stress granules (upon cellular s |
| Molecular Weight | 71 kDa |
| Amino Acids | 643 aa |
| Exons | 18 |
| Ensembl ID | ENSG00000136444 |
| GeneCards | DARS1 |
| Human Protein Atlas | DARS1 |
| Pre-mRNA splicing | DARS1 associates with spliceosomal components |
| tRNA maturation | Involvement in tRNA processing and quality control |
| RNA stability | Role in specific RNA degradation pathways |
| Stress response | DARS1 translocates to stress granules |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
A["Upstream Regulators"] --> B["DARS1"]
B --> C["Molecular Mechanism"]
C --> D["Cellular Effects"]
D --> E["Pathological Consequences"]| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||