Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PPARGC1A, NRF1, TFAM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Ancestry-Adapted Mitochondrial Rescue Therapy | 0.448 | neurodegeneration | How do neurodegeneration gene expression |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Study on the role of Dihuang Yinzi in regulating the AMPK/SIRT1/PGC-1α pathway t [PMID:39341266] | Zhu C, Zhang Z, Zhu Y, Du Y, Han C et al | J Ethnopharmacol | 2025 | 0 |
| Beneficial effects of the herbal medicine zuo gui wan in a mice model of Alzheim [PMID:39884486] | Yan X, Yang Y, Huang W, Fu S, Cui B et a | J Ethnopharmacol | 2025 | 0 |
| SIRT2 alleviates pre-eclampsia via prompting mitochondrial biogenesis and functi [PMID:40118268] | Hou R, Yang X, Xu Q, Shen C, Zhang L et | Life Sci | 2025 | 0 |
| Downregulation of Nrf2 deteriorates cognitive impairment in APP/PS1 mice by inhi [PMID:40915567] | Luo W, Bu W, Zhang G, Dong Y, Wang Y et | Behav Brain Res | 2025 | 0 |
| PSMD4 Alleviates Aβ₁₋₄₂-Induced Mitochondrial Dysfunction and Oxidative Stress v [PMID:41269417] | Yuan M, Han XJ, Luo CQ, Pan HL, Zhou HY | Mol Neurobiol | 2025 | 0 |
| GLIS3: A novel transcriptional regulator of mitochondrial functions and metaboli [PMID:39505148] | Collier JB, Kang HS, Roh YG, Srivastava | Mol Metab | 2024 | 0 |
| Overexpression of pigment epithelium-derived factor in placenta-derived mesenchy [PMID:32724163] | Kim JY, Park S, Park SH, Lee D, Kim GH e | Lab Invest | 2021 | 0 |