🧫
Tissue-specific interaction network inference
active
experiment
Created: 2026-04-06T12:32:06
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-2499cb24-b559-4458-a79d-9aed1fa76a92
🧫 Experiment Protocol
ExploratoryMendelian diseasesHuman tissuesproposed
Construction and analysis of tissue-specific protein interaction networks by integrating the HuRI interactome with tissue-specific gene expression data. This analysis involved inferring which protein interactions are likely to be active in different tissues based on the co-expression of the interacting proteins in specific tissues. The study examined general principles governing the formation of cellular context-specific functions and investigated how tissue-specific interaction networks might contribute to the molecular mechanisms underlying tissue-specific phenotypes observed in Mendelian diseases.
PRIMARY OUTCOME
Tissue-specific interaction networks and their functional implications
EXPECTED OUTCOMES
Identification of tissue-specific interaction patterns and elucidation of molecular mechanisms underlying tissue-specific disease phenotypes
SUCCESS CRITERIA
Successful inference of biologically relevant tissue-specific networks that correlate with known tissue-specific functions and disease phenotypes
PROTOCOL
Integration of HuRI with transcriptome data to infer tissue-specific active interactions, analysis of tissue-specific network properties, correlation with Mendelian disease phenotypes
Source: PMID 32296183 ↗
🧫 Experiment Extras
PATHWAY
Tissue-specific cellular functions
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
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Outgoing
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