🧫
Intensive Medical Treatment vs Usual Care in Women with ANOCA/INOCA
active
experiment
Created: 2026-04-10T22:45:21
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-7acf13c8-c5b1-41f0-997a-f555c3011129
🧫 Experiment Protocol
Clinicalangina with no obstructive coronary artery disease (ANOCA/INOCA)human patientsproposed
This was a randomized, prospective, blinded-outcomes evaluation clinical trial conducted across 71 sites in the USA to determine if intensive medical treatment (IMT) reduces major ischemic events among women with angina due to suspected ischemia but no obstructive coronary artery disease (ANOCA/INOCA). The trial randomized 2,476 women to either intensive medical treatment consisting of high-intensity statin, ACE inhibitor or angiotensin receptor blocker, and aspirin versus usual care. The study population had a mean age of 64 years with well-controlled blood pressure and low-density lipoprotein cholesterol at baseline, and relatively high rates of baseline statin and ACEI/ARB use. The trial followed participants for 2.5 years to assess cardiovascular outcomes.
PRIMARY OUTCOME
major adverse cardiovascular events (MACE): all-cause death, myocardial infarction, stroke/transient ischemic attack, hospitalization for angina or heart failure
EXPECTED OUTCOMES
Reduction in major adverse cardiovascular events with intensive medical treatment compared to usual care
SUCCESS CRITERIA
Statistically significant reduction in MACE in the intensive medical treatment group compared to usual care group
PROTOCOL
Randomized controlled trial with participants assigned to intensive medical treatment (high-intensity statin + ACE inhibitor or ARB + aspirin) versus usual care. Blinded outcomes evaluation conducted over 2.5 years of follow-up across 71 US sites.
Source: PMID 41932694 ↗
🧫 Experiment Extras
PATHWAY
cardiovascular risk reduction pathway
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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