Clinical experiment designed to assess clinical efficacy targeting N/A in human patients. Primary outcome: major adverse cardiovascular events (MACE): all-cause death, myocardial infarction, stroke/transient
This was a randomized, prospective, blinded-outcomes evaluation clinical trial conducted across 71 sites in the USA to determine if intensive medical treatment (IMT) reduces major ischemic events among women with angina due to suspected ischemia but no obstructive coronary artery disease (ANOCA/INOCA). The trial randomized 2,476 women to either intensive medical treatment consisting of high-intensity statin, ACE inhibitor or angiotensin receptor blocker, and aspirin versus usual care. The study population had a mean age of 64 years with well-controlled blood pressure and low-density lipoprotein cholesterol at baseline, and relatively high rates of baseline statin and ACEI/ARB use. The trial followed participants for 2.5 years to assess cardiovascular outcomes.
Reduction in major adverse cardiovascular events with intensive medical treatment compared to usual care
Statistically significant reduction in MACE in the intensive medical treatment group compared to usual care group
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