gene 972 words KG: ACE 2026-03-24
kind:genesection:genesstate:published
Contents

ACE Gene

🧬 Gene Info
Gene SymbolACE
Full NameAngiotensin-Converting Enzyme
AliasesACE1, CD143, DCP1
Chromosome17q23.3
Protein TypeProtease
FunctionConverts angiotensin I to angiotensin II
Molecular Weight149.7 kDa
Amino Acids1306
PathwaysRenin-angiotensin system, Bradykinin metabolism
UniProt IDP12821
NCBI Gene ID1636
Ensembl IDENSG00000159640
OMIM106180
GeneCardsACE
Human Protein AtlasACE
Associated DiseasesALS, Alzheimer, Alzheimer's disease, Cardiac, Depression
InteractionsTNF, STAT1, EGFR, NUP98, UBIQUITIN, TAU
SciDEX HypothesesMicroglial ACE Enhancement for Amyloid Clearance
KG Connections360 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Microglial ACE Enhancement for Amyloid Clearance
Score: 0.40
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.49
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.45

Related Analyses (16)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Extracellular vesicle biomarkers for early AD detection
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · failed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

Related Experiments (5)

Plasma ATN biomarkers across AD continuum in Chilean cohort
clinical · proposed · Score: 0.95
Intensive Medical Treatment vs Usual Care in Women with ANOC
clinical · proposed · Score: 0.95
ACEs and Motoric Cognitive Risk Syndrome in Chinese Older Ad
clinical · proposed · Score: 0.95
Preinjury ACE-I/ARB exposure and outcomes in transfused trau
clinical · proposed · Score: 0.95
N-of-1 Clinical Trial Design for CBS/PSP
clinical · proposed · Score: 0.40

See Also (15)

BEACoN Study - Biomarker Exploration in Aging, Cognitio
clinical · Pages share 6 hypotheses
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
adam17
gene · KG edge: associated_with
ABI3 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

ACE provides_data_for ds-83b31ef18d49
ACE activates TNF
ACE therapeutic_target TREM2
ACE therapeutic_target PILRA
ACE therapeutic_target IDUA
ACE therapeutic_target TAU
ACE therapeutic_target GRN
ACE expressed_in NDUFS8
ACE expressed_in LDLR
ACE expressed_in CLU