Validation experiment designed to validate causal mechanisms targeting SNCA in A53T BAC-SNCA transgenic mice. Primary outcome: α-synuclein pathology spread and neurodegeneration
This comprehensive experiment evaluated the disease-modifying potential of perampanel in A53T BAC-SNCA transgenic mice injected with PFFs. Mice received PFF injections followed by either perampanel or vehicle treatment for 2 and 9 months after PFF removal. The study assessed α-synuclein pathology spreading from first-order injection sites to second- and higher-order brain regions, as well as neurodegeneration. This experiment directly tests whether perampanel can prevent transsynaptic propagation of α-synuclein pathology and associated neuronal loss.
PFF injection followed by perampanel or vehicle treatment for 2 and 9 months, with assessment of pathology in different brain regions
reduced α-synuclein pathology in distant regions and ameliorated neurodegeneration with perampanel treatment
significant reduction in pathology spread to second/higher-order regions and reduced neurodegeneration
No debates yet
No results recorded yet. Use POST /api/experiments/{id}/results to record a result.