Quantitative proteomics of the aging synapse in early Alzheimer disease

Analysis ID: SDA-2026-04-04-frontier-proteomics-1c3dba72

Domain: neurodegeneration

Notebook stub generated by recurring CI coverage task.

Research Question

What are the critical protein expression changes and post-translational modifications (phosphorylation, ubiquitination, glycosylation) at the aging synapse that drive early Alzheimer disease pathophysiology? Focus on: (1) synaptic vesicle proteins and their PTM states, (2) scaffold proteins and their altered interactions, (3) receptor tyrosine kinase signaling cascades, (4) mitochondrial proteins at the synapse, and (5) proteins involved in amyloid precursor protein processing. How do these proteomic changes correlate with cognitive decline and which represent therapeutic intervention points?