Mitochondrial Dysfunction as a Driver of Neurodegeneration
How does mitochondrial dysfunction drive neurodegeneration across AD, PD, and ALS? Characterize PINK1/Parkin mitophagy pathway, mtDNA damage, ETC complex activity, and ROS generati
Tau Pathology Propagation in Tauopathies — Mechanistic Dissection
How does misfolded tau spread through the brain in tauopathies? Characterize prion-like propagation mechanisms, cell-to-cell transfer, and the role of MAPT mutations, ApoE genotype
Neuroinflammation and microglial priming in early Alzheimer's Disease — Analysis Notebook
Mechanistic links between early microglial priming states, neuroinflammatory signaling, and AD progression. Forge-powered analysis with 14 hypotheses, 105 KG edges, and PubMed cita
CRISPR-based therapeutic approaches for neurodegenerative diseases — Analysis Notebook
CRISPR-based therapeutic approaches for neurodegenerative diseases (Alzheimer, Parkinson, Huntington). Forge-powered analysis with 14 hypotheses, 431 KG edges, and PubMed citations
SEA-AD Gene Expression Analysis: Microglia vs Neurons
Differential gene expression analysis of Alzheimer's disease-related genes comparing microglia and neurons using Seattle Alzheimer's Disease Brain Cell Atlas (SEA-AD) data. Includes heatmap, volcano p
Cell-Type Vulnerability in Alzheimer's Disease — SEA-AD Transcriptomics (v3)
What cell types are most vulnerable in Alzheimer's Disease based on SEA-AD transcriptomic data? Identify differential gene expression, vulnerability scores, and regulatory networks in excitatory neuro
Cell-Type Vulnerability in Alzheimer's Disease — SEA-AD Transcriptomics (v4)
Extended SEA-AD analysis: identify cell-type-specific gene regulatory networks that predict vulnerability. Focus on super-enhancer-linked genes, TF binding, and cross-cell-type communication in AD-aff
Epigenetic Reprogramming in Aging Neurons — Mechanistic Analysis
Investigate mechanisms of epigenetic reprogramming in aging neurons. How do changes in DNA methylation, histone modification, and chromatin remodeling contribute to neurodegeneration risk?
Extracellular Vesicle Biomarkers for Early Alzheimer's Disease Detection
Which extracellular vesicle (EV) cargo proteins best discriminate early AD from controls? Characterize EV proteome from plasma, CSF, and brain tissue across disease stages using multi-cohort data.
SEA-AD v4: Inhibitory Neuron Subtypes and Circuit Vulnerability in AD
Which inhibitory neuron subtypes show earliest transcriptomic divergence in AD? Characterize Sst, Pvalb, and Vip+ interneuron vulnerability and link to circuit dysfunction biomarkers.