Computational analysis artifacts linked to analyses and knowledge graph entities
How does mitochondrial dysfunction drive neurodegeneration across AD, PD, and ALS? Characterize PINK1/Parkin mitophagy pathway, mtDNA damage, ETC complex activity, and ROS generati
How does misfolded tau spread through the brain in tauopathies? Characterize prion-like propagation mechanisms, cell-to-cell transfer, and the role of MAPT mutations, ApoE genotype
Mechanistic links between early microglial priming states, neuroinflammatory signaling, and AD progression. Forge-powered analysis with 14 hypotheses, 105 KG edges, and PubMed cita
Forge-powered analysis: 28 hypotheses, 216 KG edges, PubMed + STRING + Open Targets + ClinVar. 10 code cells, 5 plots.
CRISPR-based therapeutic approaches for neurodegenerative diseases (Alzheimer, Parkinson, Huntington). Forge-powered analysis with 14 hypotheses, 431 KG edges, and PubMed citations
Gene expression analysis notebook for Can senolytics targeting senescent cells slow neurodegeneration?
Enhanced notebook with gene expression, pathway enrichment, and statistical analysis for: Investigate prion-like spreading of tau pathology through connected brain regions, focusing on trans
Enhanced notebook with gene expression, pathway enrichment, and statistical analysis for: What are the mechanisms underlying neuroinflammation resolution mechanisms and pro-resolving mediato
Enhanced notebook with gene expression, pathway enrichment, and statistical analysis for: What are the mechanisms underlying apoe4 structural biology and therapeutic targeting strategies?