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Computational analysis artifacts linked to analyses and knowledge graph entities

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Mitochondrial Dysfunction as a Driver of Neurodegeneration

How does mitochondrial dysfunction drive neurodegeneration across AD, PD, and ALS? Characterize PINK1/Parkin mitophagy pathway, mtDNA damage, ETC complex activity, and ROS generati

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Created: 2026-04-12

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Tau Pathology Propagation in Tauopathies — Mechanistic Dissection

How does misfolded tau spread through the brain in tauopathies? Characterize prion-like propagation mechanisms, cell-to-cell transfer, and the role of MAPT mutations, ApoE genotype

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Created: 2026-04-12

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Neuroinflammation and microglial priming in early Alzheimer's Disease — Analysis Notebook

Mechanistic links between early microglial priming states, neuroinflammatory signaling, and AD progression. Forge-powered analysis with 14 hypotheses, 105 KG edges, and PubMed cita

showcase forge-tools neuroinflammation neurodegeneration

📊 Neuroinflammation and microglial priming in early Alzheimer's Disease

Created: 2026-04-11

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Gene expression changes in aging mouse brain predicting neurodegenerative vulnerability — Analysis Notebook

Forge-powered analysis: 28 hypotheses, 216 KG edges, PubMed + STRING + Open Targets + ClinVar. 10 code cells, 5 plots.

showcase forge-tools transcriptomics neurodegeneration

📊 Gene expression changes in aging mouse brain predicting neurodegenerative vulnerability

Created: 2026-04-11

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CRISPR-based therapeutic approaches for neurodegenerative diseases — Analysis Notebook

CRISPR-based therapeutic approaches for neurodegenerative diseases (Alzheimer, Parkinson, Huntington). Forge-powered analysis with 14 hypotheses, 431 KG edges, and PubMed citations

showcase forge-tools gene-editing neurodegeneration

📊 CRISPR-based therapeutic approaches for neurodegenerative diseases

Created: 2026-04-11

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All Notebooks (7) (filtered by: tau)

Tau propagation mechanisms and therapeutic interception points

Analysis ID: SDA-2026-04-02-gap-tau-prop-20260402003221

gene-expression microglia neurodegeneration statistics tau

📊 Tau propagation mechanisms and therapeutic interception points (neurodegeneration)

Created: 2026-04-02

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Tau Propagation Mechanisms and Therapeutic Interception Points

Analysis ID: SDA-2026-04-02-gap-tau-propagation-20260402 Date: 2026-04-02 Domain: Neurodegeneration -- Tauopathies

neurodegeneration statistics tau

📊 Tau propagation mechanisms and therapeutic interception points (neurodegeneration)

Created: 2026-04-02

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Tau propagation mechanisms and therapeutic interception points

Analysis ID: SDA-2026-04-02-gap-tau-prop-20260402003221 Date: 2026-04-02 Domain: neurodegeneration Hypotheses Generated: 7 Knowledge Graph Edges: 77

SEA-AD gene-expression hypothesis-analysis microglia neurodegeneration

📊 Tau propagation mechanisms and therapeutic interception points (neurodegeneration)

Created: 2026-04-02

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Tau propagation mechanisms and therapeutic interception points - Rich Analysis Notebook

Enhanced notebook with gene expression, pathway enrichment, and statistical analysis for: Investigate prion-like spreading of tau pathology through connected brain regions, focusing on trans

Tau Protein Propagation Alzheimer's Therapeutics

📊 Tau propagation mechanisms and therapeutic interception points (neurodegeneration)

Created: 2026-04-02

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Sleep disruption as cause and consequence of neurodegeneration — Statistical Deep Dive

Analysis ID: SDA-2026-04-01-gap-v2-18cf98ca Date: 2026-04-03

gene-expression microglia neurodegeneration statistics tau

📊 Sleep disruption as cause and consequence of neurodegeneration (neurodegeneration)

Created: 2026-04-01

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Sleep Disruption as Cause and Consequence of Neurodegeneration

How do sleep disruptions both drive and result from neurodegenerative disease processes, and what therapeutic opportunities exist in this bidirectional relationship?

gene-expression microglia neurodegeneration statistics tau

📊 Sleep disruption as cause and consequence of neurodegeneration (neurodegeneration)

Created: 2026-04-01

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Sleep disruption as cause and consequence of neurodegeneration

What are the mechanisms underlying sleep disruption as cause and consequence of neurodegeneration?

gene-expression hypothesis-analysis microglia neurodegeneration statistics

📊 Sleep disruption as cause and consequence of neurodegeneration (neurodegeneration)

Created: 2026-04-01

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