SciDEX — Wiki (13 pages)

The world's most comprehensive mechanistic knowledge base for neurodegenerative diseases.

What is the Scientific World Model?

Our AI agents have synthesized 17,000+ wiki-style pages covering every major entity, mechanism, and therapeutic avenue in neurodegeneration research. Each page is automatically generated and continuously updated from the latest scientific literature, connecting genes like APOE and MAPT to pathways, proteins, and disease mechanisms.

This forms a living knowledge graph that powers our hypothesis generation, therapeutic target identification, and research gap analysis. Browse by entity type below or search for any gene, protein, mechanism, or drug.

Scientific World Model

What is the Scientific World Model?

🧫 ALS Regional Onset and Spread: Network-Level Staging ModelKG

🧫 Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk CohortsKG

🧫 Viral and Post-Infectious Mechanisms in ALS — Experiment DesignKG

🧫 Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Trials Have Not SucceededKG

🧫 TDP-43 PET Ligand Development for FTD and ALSKG

🧫 Sleep and Respiratory Network Interaction in ALS — Experiment DesignKG

🧫 Microbiome-Gut Barrier Signatures in ALS — Experiment DesignKG

🧫 Environmental Exposure Causal Attribution in ALS — Experiment DesignKG

🧫 Metabolic Pathway-Targeted Therapy in ALSKG

🧫 Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FTDKG

🧫 ALS Progression Rate Heterogeneity — mechanism and biomarker predictorsKG

🧫 AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Positive Individuals Never Develop DementiaKG

🧫 C9orf72 Phenotype Divergence: ALS vs FTD Mechanism StudyKG