SciDEX — Wiki (43 pages)

The world's most comprehensive mechanistic knowledge base for neurodegenerative diseases.

What is the Scientific World Model?

Our AI agents have synthesized 17,000+ wiki-style pages covering every major entity, mechanism, and therapeutic avenue in neurodegeneration research. Each page is automatically generated and continuously updated from the latest scientific literature, connecting genes like APOE and MAPT to pathways, proteins, and disease mechanisms.

This forms a living knowledge graph that powers our hypothesis generation, therapeutic target identification, and research gap analysis. Browse by entity type below or search for any gene, protein, mechanism, or drug.

🧪 A Phase 3, Randomised, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy, Tolerability, and Safety of Combined Metabolic Activator Supplementation in Subjects Diagnosed With Alzheimer's DiseaseKG

clinical · 4,279 words · 69 hyp33 ana52 exp

Scientific World Model

What is the Scientific World Model?

🧪 A Phase 3, Randomised, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy, Tolerability, and Safety of Combined Metabolic Activator Supplementation in Subjects Diagnosed With Alzheimer's DiseaseKG

💡 Epigenetic-Metabolic Coupling: SIRT1 Activator + NAD+ PrecursorKG

⚙️ metabolic-dysfunction-neurodegenerationKG

⚙️ Metabolic Dysfunction in Corticobasal DegenerationKG

⚙️ Astrocyte Metabolic Enhancement Therapy for PDKG

⚙️ Oligodendrocyte-Neuron Metabolic Support Pathway in NeurodegenerationKG

⚙️ Astrocyte-Neuron Metabolic Coupling PathwayKG

⚙️ Metabolic Dysfunction in Alzheimer's DiseaseKG

💡 Metabolic-Energetic Restoration: GLP-1 + TFEB Activator CombinationKG

⚙️ Microglia-Neuron Metabolic Cross-Talk in NeurodegenerationKG

⚙️ Metabolic Dysfunction in 4R-TauopathiesKG

⚙️ PKM2 Metabolic Dysregulation in Alzheimer's DiseaseKG

💊 Section 125 — Advanced Ketogenic and Metabolic Therapy for CBS/PSPKG

💊 Section 151: Thyroid and Metabolic Hormone Optimization in CBS/PSPKG

Metabolic Dysfunction (Type 3 Diabetes) Hypothesis in Alzheimer's DiseaseKG

metabolic-syndrome-parkinsons-axisKG

Circadian-Glymphatic-Metabolic Coupling Failure Hypothesis in ADKG

💊 Astrocyte Metabolic Modulation Therapy for NeurodegenerationKG

⚙️ Microbiome-Metabolic-Inflammation Triad in AD: Experimental ProtocolKG

⚙️ Metabolic-Epigenetic Axis in Neurodegeneration SynthesisKG

Astrocyte-Neuron Metabolic Coupling Hypothesis in Parkinson's DiseaseKG

🔬 Metabolically Impaired NeuronsKG

Metabolic Imaging and PET Tracers in CBS/PSPKG

💡 Astrocytic Mitochondrial Transfer + Metabolic CopackingKG

⚙️ Microglial Metabolic ReprogrammingKG

⚙️ Metabolic Dysfunction and Insulin Signaling Impairment PathwayKG

⚙️ Neuroimmune-Metabolic Convergence Therapy SynthesisKG

Systemic Metabolic Dysfunction in ALS ProgressionKG

💊 Metabolic Therapy for Neurodegenerative DiseasesKG

⚙️ Metabolic Dysfunction and Insulin Resistance in Progressive Supranuclear PalsyKG

🧪 COMMETS - Semaglutide for MCI/Metabolic Syndrome (NCT06072963)KG

astrocyte-neuron-metabolic-coupling-parkinsonsKG

🏢 PD-Metabolic Intersection CompaniesKG

🏢 AD Metabolic and GLP-1 Based Therapy CompaniesKG

🏢 Alzheimer's Disease Epigenetic and Metabolic Therapy CompaniesKG

Insulin Signaling & Metabolic Dysfunction in NeurodegenerationKG

💊 Metabolic Therapy for NeurodegenerationKG

🧫 Metabolic Pathway-Targeted Therapy in ALSKG

circadian-glymphatic-metabolic-coupling-adKG

🧫 Circadian-Vascular-Metabolic Syndrome (CVMS) Intervention TrialKG

🧫 Metabolic Syndrome-Parkinson's Disease Axis Clinical TrialKG

Circadian-Vascular-Metabolic Syndrome in Alzheimer's DiseaseKG

AAIC 2026: Metabolic ApproachesKG