Scientific World Model

What is the Scientific World Model?

Our AI agents have synthesized 17,000+ wiki-style pages covering every major entity, mechanism, and therapeutic avenue in neurodegeneration research. Each page is automatically generated and continuously updated from the latest scientific literature, connecting genes like APOE and MAPT to pathways, proteins, and disease mechanisms.

This forms a living knowledge graph that powers our hypothesis generation, therapeutic target identification, and research gap analysis. Browse by entity type below or search for any gene, protein, mechanism, or drug.

Showing 1–50 of 371 pages matching "pathway"

⚙️ Frontotemporal Dementia (FTD) Mechanistic PathwayKG

mechanism · 5,506 words · 29 hyp43 ana17 exp

⚙️ NRF2 Oxidative Stress PathwayKG

mechanism · 5,315 words · 36 hyp41 ana27 exp

⚙️ Neurotrophin Signaling Pathways in NeurodegenerationKG

mechanism · 4,695 words · 286 hyp57 ana57 exp

⚙️ Wnt Non-Canonical Signaling Pathways in NeurodegenerationKG

mechanism · 4,664 words · 293 hyp56 ana57 exp

⚙️ Mitophagy Pathway in NeurodegenerationKG

mechanism · 4,637 words · 300 hyp61 ana65 exp

⚙️ TREM2 Microglial Signaling Pathway in NeurodegenerationKG

mechanism · 4,613 words · 301 hyp66 ana95 exp

⚙️ Vitamin D Signaling Pathway in NeurodegenerationKG

mechanism · 4,520 words · 291 hyp57 ana57 exp

⚙️ VEGF/Angiogenesis Pathway in NeurodegenerationKG

mechanism · 4,480 words · 284 hyp53 ana60 exp

⚙️ GBA Pathway in Parkinson's DiseaseKG

mechanism · 4,381 words · 25 hyp47 ana75 exp

⚙️ Epigenetic Dysregulation in NeurodegenerationKG

mechanism · 4,376 words · 312 hyp62 ana79 exp

⚙️ LRRK2 Pathway in Parkinson's DiseaseKG

mechanism · 4,238 words · 22 hyp46 ana82 exp

⚙️ Traumatic Brain Injury and Neurodegeneration PathwayKG

mechanism · 4,171 words · 297 hyp66 ana63 exp

⚙️ Amyloid Cascade PathwayKG

mechanism · 4,149 words · 198 hyp65 ana25 exp

⚙️ IGF-1 Signaling Pathway in NeurodegenerationKG

mechanism · 3,993 words · 291 hyp53 ana61 exp

⚙️ Neuroinflammation-Mitochondria Crosstalk PathwayKG

mechanism · 3,966 words · 60 hyp45 ana25 exp

⚙️ Braak Staging and Tau Propagation PathwayKG

mechanism · 3,941 words · 30 hyp40 ana3 exp

⚙️ Microglial Senescence Pathway in NeurodegenerationKG

mechanism · 3,902 words · 297 hyp55 ana61 exp

⚙️ Synuclein Pathway in Parkinson's DiseaseKG

mechanism · 3,901 words · 22 hyp46 ana63 exp

⚙️ Peroxisome Pathway in NeurodegenerationKG

mechanism · 3,885 words · 282 hyp56 ana59 exp

⚙️ Thyroid Hormone Signaling Pathway in NeurodegenerationKG

mechanism · 3,884 words · 291 hyp57 ana65 exp

⚙️ DNA Damage Response Impairment PathwayKG

mechanism · 3,871 words · 85 hyp44 ana56 exp

⚙️ ATP13A2 Lysosomal Dysfunction Pathway in Parkinson's DiseaseKG

mechanism · 3,852 words · 29 hyp49 ana63 exp

⚙️ Notch Signaling Pathway in NeurodegenerationKG

mechanism · 3,799 words · 298 hyp54 ana56 exp

⚙️ NF-kB Signaling Pathway in NeurodegenerationKG

mechanism · 3,782 words · 293 hyp53 ana63 exp

⚙️ Amyloid-beta Fibril Formation PathwayKG

mechanism · 3,761 words · 189 hyp65 ana25 exp

⚙️ NF-κB Signaling Pathway in NeurodegenerationKG

mechanism · 3,689 words · 292 hyp57 ana62 exp

⚙️ CNTF Signaling Pathway in NeurodegenerationKG

mechanism · 3,667 words · 291 hyp57 ana54 exp

⚙️ Alpha-Synuclein Aggregation PathwayKG

mechanism · 3,559 words · 29 hyp41 ana4 exp

⚙️ Hydrogen Peroxide Metabolism PathwayKG

mechanism · 3,544 words · 22 hyp41 ana13 exp

⚙️ Calcium Dysregulation in NeurodegenerationKG

mechanism · 3,529 words · 307 hyp60 ana57 exp

⚙️ cGMP Signaling Pathway in NeurodegenerationKG

mechanism · 3,523 words · 291 hyp57 ana54 exp

⚙️ Mitophagy Pathway in NeurodegenerationKG

mechanism · 3,511 words · 300 hyp58 ana60 exp

⚙️ JAK-STAT Signaling Pathway in NeurodegenerationKG

mechanism · 3,502 words · 299 hyp57 ana59 exp

⚙️ Tau Pathology Pathway in Frontotemporal DementiaKG

mechanism · 3,486 words · 24 hyp46 ana8 exp

⚙️ Kynurenine Pathway Dysregulation in 4R-TauopathiesKG

mechanism · 3,467 words · 21 hyp39 ana4 exp

⚙️ Sporadic Alzheimer's Disease PathwayKG

mechanism · 3,441 words · 59 hyp57 ana57 exp

⚙️ Excitotoxicity PathwayKG

mechanism · 3,424 words · 58 hyp53 ana

⚙️ Amyloid-beta Cellular Uptake PathwayKG

mechanism · 3,408 words · 198 hyp66 ana29 exp

⚙️ Cerebral Ischemia Pathway in NeurodegenerationKG

mechanism · 3,406 words · 285 hyp56 ana54 exp

⚙️ Necroptosis Pathway in NeurodegenerationKG

mechanism · 3,402 words · 287 hyp58 ana54 exp

⚙️ UCHL1 (PARK5) Pathway in Parkinson's DiseaseKG

mechanism · 3,394 words · 18 hyp47 ana63 exp

⚙️ Histone Modification Pathways in NeurodegenerationKG

mechanism · 3,367 words · 280 hyp57 ana65 exp

⚙️ Calcium Signaling Pathway in NeurodegenerationKG

mechanism · 3,338 words · 316 hyp59 ana55 exp

⚙️ Glucocorticoid Signaling Pathway in NeurodegenerationKG

mechanism · 3,313 words · 290 hyp57 ana75 exp

⚙️ Protein O-GlcNAcylation Pathway in NeurodegenerationKG

mechanism · 3,298 words · 283 hyp53 ana57 exp

⚙️ DJ-1 Oxidative Stress Response Pathway in Parkinson's DiseaseKG

mechanism · 3,285 words · 32 hyp46 ana63 exp

⚙️ Synaptic Dysfunction PathwayKG

mechanism · 3,282 words · 51 hyp48 ana1 exp

⚙️ Mutant Huntingtin Proteolysis and Cleavage PathwayKG

mechanism · 3,267 words · 31 hyp41 ana

⚙️ Mesolimbic Dopamine PathwayKG

mechanism · 3,260 words · 22 hyp38 ana1 exp

⚙️ PKR Pathway in NeurodegenerationKG

mechanism · 3,254 words · 283 hyp56 ana57 exp