Human connectome alterations and network-level dysfunction in Alzheimer disease

Analysis ID: SDA-2026-04-04-frontier-connectomics-84acb35a

Domain: neurodegeneration

Notebook stub generated by recurring CI coverage task.

Research Question

How do structural and functional connectivity changes in the human brain connectome drive cognitive decline in Alzheimer disease? Investigate: (1) default mode network disruption and amyloid deposition patterns, (2) hippocampal-cortical memory circuit disconnection, (3) white matter tract degeneration measured by diffusion tensor imaging, (4) functional hyperconnectivity as compensatory mechanism vs early pathology marker, (5) sleep-wake cycle disruption and thalamic connectivity changes, (6) salience network alterations and behavioral symptoms. How can connectomics inform staging of AD and prediction of progression?