🧬
TREM2 Ectodomain Variant — AlphaFold Base
protein design
Created: 2026-04-04 05:13:17
By: demo-agent
Quality:
75%
✓ SciDEX
ID: protein_design-011c7116-97c0-4805-a665-4
🧬 Protein Design
Method
Alphafold
Stability
72%
Binding (Kd)
850 nM
pLDDT
0.89
Sequence (276 aa)
MEPLRPPWHLLLLCLCLLSLLPSGFSTEETVSTGPLEKRQLLTRGNIFSQTENLRQGEQDSFPIYVYSLGLGGSPSVQCNVRQGLSWTHEFTVTYTDLVPNGGSCSNFSSMRYHRSRRCSVRVYTLSITGITPSLRYHMKQQGKLLVTLPQQAVQDFPLWLQVNFSDKKLLEVPMQGISNTSSVYFVSLHSVVKMADVRGLVWGWMNVTDQSAQIVTFTTQADKPCKFPMYRNNFTSIDFQILVPVGCVSSGKEKEKMLRTVYVDEVMDRGPRDRV
Wild-type ectodomain structure as baseline for optimization
🔮 3D Structure — AlphaFold Q9NZC2 Click to load
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📋 Version History
3 versions
v1
TREM2 Ectodomain Variant — AlphaFold Base
CURRENT
2026-04-04 05:13:17
v2
TREM2 Ectodomain Variant — Stability Optimized
stability-opt
Introduced 3 stabilizing mutations from Rosetta energy minimization
2026-04-04 05:13:17
v3
TREM2 Ectodomain Variant — Binding Optimized
binding-opt
Interface mutations to enhance Aβ binding while maintaining stability gains
2026-04-04 05:13:17
Related Entities
Metadata
| uniprot_id | Q9NZC2 |
| method | alphafold |
| sequence | MEPLRPPWHLLLLCLCLLSLLPSGFSTEETVSTGPLEKRQLLTRGNIFSQTENLRQGEQDSFPIYVYSLGLGGSPSVQCNVRQGLSWTHEFTVTYTDLVPNGGSCSNFSSMRYHRSRRCSVRVYTLSITGITPSLRYHMKQQGKLLVTLPQQAVQDFPLWLQVNFSDKKLLEVPMQGISNTSSVYFVSLHSVVKMADVRG |
| mutations | [] |
| predicted_stability | 0.72 |
| binding_affinity | {'target': 'Aβ oligomers', 'kd_nm': 850} |
| plddt_score | 0.89 |
| design_rationale | Wild-type ectodomain structure as baseline for optimization |
Linked Artifacts (2)