disease

Alzheimer's disease

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Alzheimer's disease: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12228Connections

17Hypotheses

30Analyses

50Outgoing

50Incoming

Summary

Alzheimer's disease is a disease characterized by neurodegeneration research. Key relationships include: associated with, treats, causes. Associated with Depression, Down syndrome, Obesity. Connected to 546 entities in the SciDEX knowledge graph.

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Disease Info

Associated Genes	MTOR, TREM2, Amyloid beta, amyloid beta, Aβ, APOE, DGAT2, ApoE
Therapeutic Agents	hederagenin, magnolol, Traditional Chinese medicine, phytochemicals, gemfibrozil, multi-target drugs
SciDEX Hypotheses	70 hypotheses
KG Connections	2268 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    Alzheimer_s_disease["Alzheimer's disease"] -->|"associated"| astrocyte_imbalance["astrocyte imbalance"]
    Alzheimer_s_disease["Alzheimer's disease"] -->|"biomarker for"| amyloid__["amyloid-beta"]
    Alzheimer_s_disease["Alzheimer's disease"] -->|"biomarker for"| tau["tau"]
    Alzheimer_s_disease["Alzheimer's disease"] -->|"causes"| dementia["dementia"]
    Alzheimer_s_disease["Alzheimer's disease"] -->|"associated"| beta_amyloid["beta-amyloid"]
    Alzheimer_s_disease["Alzheimer's disease"] -->|"associated"| tau_1["tau"]
    apoptosis["apoptosis"] -->|"causes"| Alzheimer_s_disease["Alzheimer's disease"]
    BECN1["BECN1"] -->|"protects against"| Alzheimer_s_disease["Alzheimer's disease"]
    MLKL["MLKL"] -->|"protects against"| Alzheimer_s_disease["Alzheimer's disease"]
    FN1["FN1"] -->|"protects against"| Alzheimer_s_disease["Alzheimer's disease"]
    style Alzheimer_s_disease fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (5085)

Target	Relation	Type	Str
ageing	associated_with	process	0.90
microglia	affects	cell_type	0.90
complement cascade	involves	pathway	0.90
necroptosis	involves	pathway	0.90
endothelial cells	affects	cell_type	0.90
hippocampus	affects	brain_region	0.90
lipid metabolism	involves	pathway	0.90
neurons	affects	cell_type	0.90
synaptic plasticity	involves	pathway	0.90
glymphatic clearance	involves	pathway	0.90
astrocytes	affects	cell_type	0.90
NF-kB signaling	involves	pathway	0.90
macrophages	affects	cell_type	0.90
blood-brain barrier	affects	brain_region	0.90
glutamate signaling	involves	pathway	0.90
epigenetic regulation	involves	pathway	0.90
cortex	affects	brain_region	0.90
unfolded protein response	involves	pathway	0.90
oligodendrocytes	affects	cell_type	0.90
pyroptosis	involves	pathway	0.90
insulin signaling	involves	pathway	0.90
cholinergic neurons	affects	cell_type	0.90
extracellular β-amyloid deposition	involves	pathological_process	0.90
neural stem cells	affects	cell_type	0.90
cGAS-STING	involves	pathway	0.90
purinergic receptor	involves	receptor	0.90
BDNF-TrkB signaling	involves	pathway	0.90
circadian regulation	involves	pathway	0.85
PROTEOMICS	has_proteomic_landscape	process	0.80
spinal cord	affects	brain_region	0.80
pericytes	affects	cell_type	0.80
GABAergic neurons	affects	cell_type	0.80
MAPK signaling	involves	pathway	0.80
PI3K-AKT-mTOR signaling	involves	pathway	0.80
ferroptosis	involves	pathway	0.80
entorhinal cortex	affects	brain_region	0.80
TGF-beta signaling	involves	pathway	0.80
cerebellum	affects	brain_region	0.80
calcium signaling	involves	pathway	0.80
β-amyloid deposition	involves	pathological_process	0.80
serotonin	disrupts	neurotransmitter	0.80
temporal lobe	affects	brain_region	0.80
axon	disrupts	organelle	0.80
nicotinic receptor	involves	receptor	0.80
cerebral cortex	affects	brain_region	0.80
endosome	disrupts	organelle	0.80
dentate gyrus	affects	brain_region	0.80
CRISPR-Cas	involves	pathway	0.80
sphingolipid metabolism	involves	pathway	0.75
purinergic signaling	involves	pathway	0.75

Incoming (7143)

Source	Relation	Type	Str
APOE4	promotes	gene	1.00
Connexin43	associated_with	protein	0.95
APP	risk_factor_for	gene	0.95
APOE	risk_factor_for	gene	0.95
donanemab	treats	drug	0.95
TREM2	risk_factor_for	gene	0.95
BIN1	risk_factor_for	gene	0.95
PICALM	risk_factor_for	gene	0.95
SV2A	biomarker_for	protein	0.95
APOE ε2	protects_against	protein	0.94
SIK2	protects_against	gene	0.92
secretory autophagy	associated_with	process	0.92
PARKIN	therapeutic_target	protein	0.92
NLRP3 inflammasome	promotes	protein	0.92
Semaglutide	therapeutic_target	drug	0.91
apoptosis	causes	process	0.90
APOE	contributes_to	gene	0.90
neuron	implicated_in	cell_type	0.90
amyloid-β	biomarker_for	protein	0.90
NLRP3 inflammasome	associated_with	protein	0.90
NLRP3	risk_factor_for	protein	0.90
Honokiol	treats	drug	0.90
TREM2	therapeutic_target	gene	0.90
sTREM2	biomarker_for	protein	0.90
GLP-1R	therapeutic_target	protein	0.90
WNT signaling	dysregulated_in	pathway	0.90
ULK1	biomarker_for	protein	0.90
impaired autophagy-lysosomal degradation	associated_with	process	0.90
TREM2 R47H	increases_risk_of	gene_variant	0.90
APOE	risk_factor	gene	0.90
bispecific brain-penetrant antibodies	treats	compound	0.90
NLRP3	activates	gene	0.90
AMPK	activates	gene	0.90
ALS	associated_with	gene	0.90
RNA	regulates	gene	0.90
TREM2	causes	gene	0.90
TREM2	expressed_in	gene	0.90
ALS	implicated_in	gene	0.90
APOE	regulates	gene	0.90
BDNF	activates	gene	0.90
APOE2	decreases_risk	gene	0.90
amyloid-β	implicated_in	compound	0.90
anti-amyloid immunotherapy	treats	therapy	0.90
lipopolysaccharide (LPS)	causes	compound	0.90
APOE	interacts_with	gene	0.90
bispecific brain-penetrant antibodies	are_for_treatment_of	compound	0.90
APOE4	increases_risk	gene	0.90
3D human neural cell culture	models	model	0.90
neurons	activates	cell_type	0.90
microglia	interacts_with	cell_type	0.90

Targeting Hypotheses (17)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound to restore hippo	0.709	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound with 40Hz gamma	0.689	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.625	Alzheimer's disease	Circuit-level neural dynamics in neurode

Closed-loop transcranial focused ultrasound to restore hippo	0.614	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.612	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.566	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic viral vector delivery via tFUS-mediated blood-br	0.557	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.554	Alzheimer's disease	Circuit-level neural dynamics in neurode
ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive	0.512	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.508	Alzheimer's disease	Circuit-level neural dynamics in neurode
Microglial TREM2 downregulation impairs damage-associated re	0.507	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
GAS6/TAM Axis Activation Stabilizes Blood-Brain Barrier to R	0.498	neuroinflammation	Why do TAM receptors protect against neu
C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV I	0.497	neurodegeneration	Are interneuron oscillation deficits com
ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo	0.493	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Epigenetic Memory Reprogramming for Alzheimer's Disease	0.467	neurodegeneration	CRISPR-based therapeutic approaches for

Mentioning Analyses (30)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
External fixation versus reverse shoulder arthroplasty for proximal humerus frac [PMID:41940987]	Vadalà A, Benelli C, Suraci F, Carta B,	Arch Orthop Trauma Surg	2026
Gray matter structural and molecular signatures in Alzheimer's disease and late- [PMID:41419068]	Yang S, Wang X, Yan Y, Zhang J, Wei Y et	J Affect Disord	2026
Cytomegalic parvalbumin neurons in fetal cases of hemimegalencephaly. [PMID:39973610]	Gelot AB, Draia-Nicolau TO, Mathieu R, S	Epilepsia	2025
Brain connectivity and transcriptional changes induced by rTMS in first-episode [PMID:40274783]	Guan M, Xie Y, Wang Z, Miao Y, Li X et a	Transl Psychiatry	2025
Single-cell RNA sequencing of adult primate neocortex reveals the regulatory dyn [PMID:40385068]	Zhang C, Xie Z, Wang N	Am J Transl Res	2025
Human stem cell-derived GABAergic interneuron development reveals early emergenc [PMID:40651475]	Bershteyn M, Zhou H, Fuentealba L, Chen	Neuron	2025
Enhancer AAV toolbox for accessing and perturbing striatal cell types and circui [PMID:40403704]	Hunker AC, Wirthlin ME, Gill G, Johansen	Neuron	2025
Forebrain assembloids support the development of fast-spiking human PVALB+ corti [PMID:40695284]	Walsh RM, Crabtree GW, Kalpana K, Jubier	Neuron	2025
Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social [PMID:40320404]	Qi C, Sima W, Mao H, Hu E, Ge J et al.	Nat Commun	2025
Distinct dendritic integration strategies control dynamics of inhibition in the [PMID:40592329]	Morabito A, Zerlaut Y, Dhanasobhon D, Be	Neuron	2025
Targeting SARM1 improves autophagic stress-induced axonal neuropathy. [PMID:37561040]	Kim HR, Lee HJ, Jeon Y, Jang SY, Shin YK	Autophagy	2024
Integrated multimodal cell atlas of Alzheimer's disease. [PMID:39402379]	Gabitto MI, Travaglini KJ, Rachleff VM,	Nat Neurosci	2024
Identification of early Alzheimer's disease subclass and signature genes based o [PMID:39650656]	Wang W, Lu J, Pan N, Zhang H, Dai J et a	Front Immunol	2024
Cortical somatostatin long-range projection neurons and interneurons exhibit div [PMID:38086373]	Fisher J, Verhagen M, Long Z, Moissidis	Neuron	2024
Locus Coeruleus-Dorsolateral Septum Projections Modulate Depression-Like Behavio [PMID:38155473]	Zhang Q, Xue Y, Wei K, Wang H, Ma Y et a	Adv Sci (Weinh)	2024
Somatostatin and the pathophysiology of Alzheimer's disease. [PMID:38484981]	Almeida VN	Ageing Res Rev	2024
Somatostatin interneurons control the timing of developmental desynchronization [PMID:38599213]	Mòdol L, Moissidis M, Selten M, Oozeer F	Neuron	2024
De novo gene synthesis by an antiviral reverse transcriptase. [PMID:39116258]	Tang S, Conte V, Zhang DJ, Žedaveinytė R	Science	2024
Signature morphoelectric properties of diverse GABAergic interneurons in the hum [PMID:37824669]	Lee BR, Dalley R, Miller JA, Chartrand T	Science	2023
Novel App knock-in mouse model shows key features of amyloid pathology and revea [PMID:35690868]	Xia D, Lianoglou S, Sandmann T, Calvert	Mol Neurodegener	2022

Alzheimer's disease

Understanding Entity Pages

Summary

Wiki Pages (21)

BICCN Human Brain Cell Atlas

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

CBS/PSP Supplements Guide

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome