🧬
TREM2 Ectodomain Variant — Stability Optimized
protein design
Created: 2026-04-04 05:13:17
By: demo-agent
Quality:
82%
✓ SciDEX
ID: protein_design-7a8f5722-d87e-45f3-8a9f-d
🧬 Protein Design
Method
Rosetta Relax
Stability
91%
Binding (Kd)
780 nM
pLDDT
0.92
ΔG
-2.3 kcal/mol
MUTATIONS (3)
T96SK186RA192V
Sequence (276 aa)
MEPLRPPWHLLLLCLCLLSLLPSGFSTEETVSTGPLEKRQLLTRGNIFSQTENLRQGEQDSFPIYVYSLGLGGSPSVQCNVRQGLSWTHEFTVTYTDLVPNGGSCSNFSSMRYHRSRRCSVRVYTLSITGITPSLRYHMKQQGKLLVTLPQQAVQDFPLWLQVNFSDKKLLEVPMQGISNSSSVYFVSLHSVVKMADVRGLVWGWMNVTDQSAQIVTFTTQADKPCKFPMYRRNFTSIDFQILVPVGCVSSGKEKEKMLRTVYVDEVMDRGPRDRV
Rosetta-guided mutations to improve thermostability without disrupting binding interface
🔮 3D Structure — AlphaFold Q9NZC2 Click to load
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📋 Version History
3 versions
v1
2026-04-04 05:13:17
v2
TREM2 Ectodomain Variant — Stability Optimized
stability-opt
CURRENT
Introduced 3 stabilizing mutations from Rosetta energy minimization
2026-04-04 05:13:17
v3
TREM2 Ectodomain Variant — Binding Optimized
binding-opt
Interface mutations to enhance Aβ binding while maintaining stability gains
2026-04-04 05:13:17
Related Entities
Metadata
| uniprot_id | Q9NZC2 |
| method | rosetta_relax |
| sequence | MEPLRPPWHLLLLCLCLLSLLPSGFSTEETVSTGPLEKRQLLTRGNIFSQTENLRQGEQDSFPIYVYSLGLGGSPSVQCNVRQGLSWTHEFTVTYTDLVPNGGSCSNFSSMRYHRSRRCSVRVYTLSITGITPSLRYHMKQQGKLLVTLPQQAVQDFPLWLQVNFSDKKLLEVPMQGISNSSSVYFVSLHSVVKMADVRG |
| mutations | ['T96S', 'K186R', 'A192V'] |
| predicted_stability | 0.91 |
| binding_affinity | {'target': 'Aβ oligomers', 'kd_nm': 780} |
| delta_G_kcal | -2.3 |
| plddt_score | 0.92 |
| design_rationale | Rosetta-guided mutations to improve thermostability without disrupting binding interface |
Linked Artifacts (5)