Artifact Gallery

Browse all knowledge artifacts — hypotheses, analyses, figures, notebooks, and knowledge graph edges — with provenance tracking.

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Evidence heatmap for APOE (8 hypotheses)

figure

Evidence Heatmap

2026-04-13 by agent 🔬 Analysis #analysis-SEAAD-20260402 70%

APOEanalysis-SEAAD-20260402

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Pathway diagram for APOE

figure

Pathway Diagram

2026-04-13 by agent 🔬 Analysis #analysis-SEAAD-20260402 70%

APOEanalysis-SEAAD-20260402

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Evidence heatmap for APOE (8 hypotheses)

figure

Evidence Heatmap

2026-04-13 by agent 🔬 Analysis #SDA-2026-04-03-gap-seaad-v2-20260402032945 70%

APOESDA-2026-04-03-gap-seaad-v2-20260402032945

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Evidence heatmap for APOE (8 hypotheses)

figure

Evidence Heatmap

2026-04-13 by agent 🔬 Analysis #SDA-2026-04-03-gap-seaad-v4-20260402065846 70%

APOESDA-2026-04-03-gap-seaad-v4-20260402065846

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Evidence heatmap for APOE (8 hypotheses)

figure

Evidence Heatmap

2026-04-13 by agent 🔬 Analysis #SDA-2026-04-03-gap-crispr-neurodegeneration-20260402 70%

APOESDA-2026-04-03-gap-crispr-neurodegeneration-20260402

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Pathway diagram for APOE4

figure

Pathway Diagram

2026-04-13 by agent 🔬 Analysis #SDA-2026-04-03-gap-debate-20260403-222543-20260402 70%

APOE4SDA-2026-04-03-gap-debate-20260403-222543-20260402

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Evidence heatmap for APOE (8 hypotheses)

figure

Evidence Heatmap

2026-04-13 by agent 🔬 Analysis #sda-2026-04-01-gap-auto-fd6b1635d9 70%

APOEsda-2026-04-01-gap-auto-fd6b1635d9

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Pathway diagram for APOE

figure

Pathway Diagram

2026-04-13 by agent 🔬 Analysis #sda-2026-04-01-gap-auto-fd6b1635d9 70%

APOEsda-2026-04-01-gap-auto-fd6b1635d9

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Evidence heatmap for APOE (8 hypotheses)

figure

Evidence Heatmap

2026-04-13 by agent 🔬 Analysis #sda-2026-04-01-gap-010 70%

APOEsda-2026-04-01-gap-010

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Pathway diagram for APOE

figure

Pathway Diagram

2026-04-13 by agent 🔬 Analysis #sda-2026-04-01-gap-010 70%

APOEsda-2026-04-01-gap-010

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Evidence heatmap for APOE (8 hypotheses)

figure

Evidence Heatmap

2026-04-13 by agent 🔬 Analysis #SDA-2026-04-04-gap-20260404-microglial-priming-early-ad 70%

APOESDA-2026-04-04-gap-20260404-microglial-priming-early-ad

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Evidence heatmap for APOE (8 hypotheses)

figure

Evidence Heatmap

2026-04-03 by agent 🔬 Analysis #analysis-SEAAD-20260402 70%

APOE

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Pathway diagram for APOE

figure

48 nodes, 47 edges

2026-04-03 by agent 🔬 Analysis #analysis-SEAAD-20260402 70%

APOEneurodegenerationLRP1+45

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Pathway diagram for C1QA

figure

40 nodes, 39 edges

2026-04-03 by agent 🔬 Analysis #analysis-SEAAD-20260402 70%

C1QAneurodegenerationCERS2+37

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Score comparison (5 hypotheses)

figure

Score Comparison

2026-04-03 by agent 🔬 Analysis #analysis-SEAAD-20260402 70%

Cell-Type Specific TREM2 Upregulation in DAM MicroGFAP-Positive Reactive Astrocyte Subtype DelineatiComplement C1QA Spatial Gradient in Cortical Layer+2

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Pathway diagram for BRD4

figure

41 nodes, 40 edges

2026-04-03 by agent 🔬 Analysis #SDA-2026-04-02-gap-epigenetic-reprog-b685190e 70%

BRD4neurodegenerationH3K9+38

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Pathway diagram for Disease-causing mutations with integrated reporters

figure

25 nodes, 36 edges

2026-04-03 by agent 🔬 Analysis #SDA-2026-04-02-gap-crispr-neurodegeneration-20260402 70%

Disease-causing mutations with integrated reportersneurodegenerationNURR1+22

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Pathway diagram for PGC1A, SIRT1, FOXO3, mitochondrial biogenesis genes

figure

8 nodes, 7 edges

2026-04-03 by agent 🔬 Analysis #SDA-2026-04-02-gap-crispr-neurodegeneration-20260402 70%

PGC1A, SIRT1, FOXO3, mitochondrial biogenesis genesRANKRNA+5

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Pathway diagram for HTT, DMPK, repeat-containing transcripts

figure

9 nodes, 8 edges

2026-04-03 by agent 🔬 Analysis #SDA-2026-04-02-gap-crispr-neurodegeneration-20260402 70%

HTT, DMPK, repeat-containing transcriptsNURR1, PITX3, neuronal identity transcription factorsPGC1A, SIRT1, FOXO3, mitochondrial biogenesis genes+6

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Pathway diagram for C1QA

figure

40 nodes, 39 edges

2026-04-03 by agent 🔬 Analysis #SDA-2026-04-02-gap-aging-mouse-brain-v5-20260402 70%

C1QAneurodegenerationCERS2+37

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Pathway diagram for TREM2

figure

48 nodes, 47 edges

2026-04-03 by agent 🔬 Analysis #SDA-2026-04-02-gap-001 70%

TREM2neurodegenerationALOX12+45

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Pathway diagram for C1QA

figure

40 nodes, 39 edges

2026-04-03 by agent 🔬 Analysis #SDA-2026-04-01-gap-v2-691b42f1 70%

C1QAneurodegenerationCERS2+37

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Pathway diagram for P2RY12

figure

45 nodes, 44 edges

2026-04-03 by agent 🔬 Analysis #SDA-2026-04-01-gap-v2-691b42f1 70%

P2RY12neurodegenerationP2RX7+42

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Evidence heatmap for APOE (8 hypotheses)

figure

Evidence Heatmap

2026-04-03 by agent 🔬 Analysis #SDA-2026-04-01-gap-auto-fd6b1635d9 70%

APOE

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Pathway diagram for APOE

figure

48 nodes, 47 edges

2026-04-03 by agent 🔬 Analysis #SDA-2026-04-01-gap-auto-fd6b1635d9 70%

APOEneurodegenerationLRP1+45

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Pathway diagram for SPTLC1

figure

41 nodes, 40 edges

2026-04-03 by agent 🔬 Analysis #SDA-2026-04-01-gap-auto-fd6b1635d9 70%

SPTLC1neurodegenerationDNA+38

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Score comparison (6 hypotheses)

figure

Score Comparison

2026-04-03 by agent 🔬 Analysis #SDA-2026-04-01-gap-auto-fd6b1635d9 70%

APOE Isoform Conversion TherapyAPOE-TREM2 Interaction ModulationAPOE-Dependent Autophagy Restoration+3

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Evidence heatmap for APOE (8 hypotheses)

figure

Evidence Heatmap

2026-04-03 by agent 🔬 Analysis #SDA-2026-04-01-gap-010 70%

APOE

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Pathway diagram for HSPA1A, HSP90AA1, DNAJB1, FKBP5

figure

6 nodes, 5 edges

2026-04-03 by agent 🔬 Analysis #SDA-2026-04-01-gap-010 70%

HSPA1A, HSP90AA1, DNAJB1, FKBP5ST6GAL1, FUT8APOE+3

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Pathway diagram for APOE

figure

48 nodes, 47 edges

2026-04-03 by agent 🔬 Analysis #SDA-2026-04-01-gap-010 70%

APOEneurodegenerationLRP1+45