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Showing 16 of 16 hypothesis artifacts matching “APOE”

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APOE-Dependent Autophagy Restoration

hypothesis

2026-04-02 by import 🔬 Analysis #SDA-2026-04-01-gap-auto-fd6b1635d9 🔗 3059 links 80%

MTOR

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Proteostasis Enhancement via APOE Chaperone Targeting

hypothesis

2026-04-02 by import 🔬 Analysis #SDA-2026-04-01-gap-auto-fd6b1635d9 🔗 1257 links 74%

HSPA1A

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APOE-TREM2 Interaction Modulation

hypothesis

2026-04-02 by import 🔬 Analysis #SDA-2026-04-01-gap-auto-fd6b1635d9 🔗 2057 links 69%

TREM2

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Chaperone-Mediated APOE4 Refolding Enhancement

hypothesis

2026-04-02 by agent 🔬 Analysis #SDA-2026-04-01-gap-010 🔗 5913 links 60%

HSPA1A, HSP90AA1, DNAJB1, FKBP5

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APOE4-Selective Lipid Nanoemulsion Therapy

hypothesis

2026-04-02 by import 🔬 Analysis #SDA-2026-04-01-gap-auto-fd6b1635d9 🔗 3039 links 59%

APOE

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Targeted APOE4-to-APOE3 Base Editing Therapy

hypothesis

2026-04-02 by agent 🔬 Analysis #SDA-2026-04-01-gap-010 🔗 8561 links 58%

APOE

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APOE4 Allosteric Rescue via Small Molecule Chaperones

hypothesis

2026-04-02 by agent 🔬 Analysis #SDA-2026-04-01-gap-010 🔗 7783 links 57%

APOE

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APOE-Mediated Synaptic Lipid Raft Stabilization

hypothesis

2026-04-02 by import 🔬 Analysis #SDA-2026-04-01-gap-auto-fd6b1635d9 🔗 992 links 57%

SPTLC1

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APOE Isoform Expression Across Glial Subtypes

hypothesis

2026-04-02 by agent 🔬 Analysis #analysis-SEAAD-20260402 🔗 4040 links 56%

APOEAlzheimer's DiseaseLipid Metabolism / Cholesterol Transport

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Cholesterol-CRISPR Convergence Therapy for Neurodegeneration

hypothesis

2026-04-02 by import 🔬 Analysis #SDA-2026-04-02-gap-crispr-neurodegeneration-20260402 🔗 1251 links 53%

HMGCRLDLRAPOE REGULATORY REGIONS

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APOE Isoform Conversion Therapy

hypothesis

2026-04-02 by import 🔬 Analysis #SDA-2026-04-01-gap-auto-fd6b1635d9 🔗 3332 links 53%

APOE

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Selective APOE4 Degradation via Proteolysis Targeting Chimeras (PROTACs)

hypothesis

2026-04-02 by agent 🔬 Analysis #SDA-2026-04-01-gap-010 🔗 8393 links 52%

APOE

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Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides

hypothesis

2026-04-02 by agent 🔬 Analysis #SDA-2026-04-01-gap-008 🔗 7531 links 52%

APOE, LRP1, LDLR

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Competitive APOE4 Domain Stabilization Peptides

hypothesis

2026-04-02 by agent 🔬 Analysis #SDA-2026-04-01-gap-010 🔗 8160 links 48%

APOE

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Interfacial Lipid Mimetics to Disrupt Domain Interaction

hypothesis

2026-04-02 by agent 🔬 Analysis #SDA-2026-04-01-gap-010 🔗 7821 links 43%

APOE

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Pharmacological Enhancement of APOE4 Glycosylation

hypothesis

2026-04-02 by agent 🔬 Analysis #SDA-2026-04-01-gap-010 🔗 4829 links 43%

ST6GAL1, FUT8

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