Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HMGB1, S100 proteins: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| DAMP-Scavenging Microglial Reset | 0.462 | - | Neuroinflammation and microglial priming |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| AGE-RAGE stress: a changing landscape in pathology and treatment of Alzheimer's [PMID:31079281] | Prasad K | Mol Cell Biochem | 2019 | 0 |
| Damage-Associated Molecular Patterns in Inflammatory Diseases. [PMID:30181915] | Roh JS, Sohn DH | Immune Netw | 2018 | 0 |
| Danger-associated molecular patterns in Alzheimer's disease. [PMID:28049142] | Venegas C, Heneka MT | J Leukoc Biol | 2017 | 0 |
| Role of advanced glycation end products in cellular signaling. [PMID:24624331] | Ott C, Jacobs K, Haucke E, Navarrete San | Redox Biol | 2014 | 0 |
| RAGE in tissue homeostasis, repair and regeneration. [PMID:23103427] | Sorci G, Riuzzi F, Giambanco I, Donato R | Biochim Biophys Acta | 2013 | 0 |
| Receptor for age (RAGE) is a gene within the major histocompatibility class III [PMID:11578972] | Schmidt AM, Stern DM | Front Biosci | 2001 | 0 |