| Gene Symbol | AGER |
| Full Name | AGER/RAGE |
| Chromosome | 6p21.3 |
| Protein Type | Receptor |
| Target Class | Protein |
| Function | RAGE is a multi-ligand receptor that binds: - Advanced glycation end products (AGEs) - HMGB1 (High Mobility Group Box 1) - S100B protein - Amyloid-beta fibrils - DNA release from damaged cells |
| Mechanism of Action | Prioritized from 1 SciDEX hypotheses, including: Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuroinflammatory Cascade |
| Druggability | Medium (0.50) |
| Clinical Stage | Phase I |
| Pathways | NF-κB, MAPK |
| UniProt ID | Q15120 |
| NCBI Gene ID | 177 |
| OMIM | 600841 |
| GeneCards | AGER |
| Human Protein Atlas | AGER |
| Associated Diseases | AD, ALI, ALS, Alzheimer's disease, Cardiovascular |
| Interactions | HSPA1A, HSPA1B, NCOA4, EGFR, RAGE, HLA |
| SciDEX Target | View Target Profile |
| SciDEX Hypotheses | Blocking AGE-RAGE Signaling in Enteric Glia to Pre |
| KG Connections | 152 knowledge graph edges |
| Databases | GeneCardsHPASTRING |