therapeutic 1,719 words KG: ent-gene-51bff6c4 2026-03-31
kind:therapeuticsection:therapeuticsstate:publishedtopic:s100-protein-modulation
Contents

S100 Protein (S100A8/A9/A12) Modulator Therapy for Neurodegeneration

🔬 Protein Info
Gene Symbolent-gene-51bff6c4
CompoundMechanism
Paquinimod (ABC015)Preclinical
Linosporine derivativesPreclinical
Peptide inhibitorsDiscovery
S100A9 neutralizing antibodiesPreclinical
DrugStatus
TTP-488 (PF-04494700)Aztrek/NIH
FPS-ZM1Research compound
RAGE decoy receptorsResearch
MCC950Research
Dapansutrile (OLT1177)Phase 2
CRID3Research
GlycyrrhizinDirect S100B binding
StatinsS100 expression reduction
MinocyclineMicroglial activation suppression
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
CYP46A1 Overexpression Gene Therapy
Score: 0.63

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · proposed · Score: 0.40
s:** - Biochemical binding assays measuring PROTAC selectivi
falsification · proposed · Score: 0.40
Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40
Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40

See Also (15)

Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 139 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 139 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 139 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 139 hypotheses
Vagus Nerve Pathway in Neurodegeneration
mechanism · Pages share 139 hypotheses

Knowledge Graph (2 edges)

ent-gene-51bff6c4 data_in benchmark_ot_ad_answer_key:S100A8
benchmark_ot_ad_answer_key:S100A8 data_in ent-gene-51bff6c4