Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PKN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | PKN1 |
| Full Name | Protein Kinase N1 |
| Chromosome | 19p13.12 |
| Protein Type | Kinase |
| Function | PKN1 (Protein Kinase N1) encodes a serine/threonine protein kinase that belongs to the protein kinase C (PKC) superfamily but represents a distinct branch (the PKN or protein kinase N family). |
| Primary Expression | most tissues, with high expression in brain, heart, and skeletal muscle |
| Pathways | MAPK, NF-κB |
| UniProt ID | [Q16512](https://www.uniprot.org/uniprot/Q16512) |
| Ensembl ID | ENSG00000123143 |
| GeneCards | PKN1 |
| Human Protein Atlas | PKN1 |
| Cytoskeletal regulation | Controls actin stress fiber formation, microtubule organization, and neuronal process outgrowth |
| Cell adhesion | Regulates integrin-mediated adhesion and focal adhesion dynamics |
| Signal transduction | Links Rho GTPase signaling to downstream effectors including MAPK and NF-κB pathways |
| Cell survival | Modulates apoptosis and cell survival pathways in response to cellular stress 3 |
| Associated Diseases | neurodegeneration |
| Interactions | ALS |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["PKN1"]
N1["TDP-43"]
N1 -->|"regulates"| N0
N2["ALS"]
N2 -->|"activates"| N0
N3["neurodegeneration"]
N0 -->|"implicated in"| N3
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class N0 gene
class N1 protein
class N2 gene| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||