| Gene Symbol | PKN1 |
| Full Name | Protein Kinase N1 |
| Chromosome | 19p13.12 |
| Protein Type | Kinase |
| Function | PKN1 (Protein Kinase N1) encodes a serine/threonine protein kinase that belongs to the protein kinase C (PKC) superfamily but represents a distinct branch (the PKN or protein kinase N family). |
| Primary Expression | most tissues, with high expression in brain, heart, and skeletal muscle |
| Pathways | MAPK, NF-κB |
| UniProt ID | [Q16512](https://www.uniprot.org/uniprot/Q16512) |
| Ensembl ID | ENSG00000123143 |
| GeneCards | PKN1 |
| Human Protein Atlas | PKN1 |
| Cytoskeletal regulation | Controls actin stress fiber formation, microtubule organization, and neuronal process outgrowth |
| Cell adhesion | Regulates integrin-mediated adhesion and focal adhesion dynamics |
| Signal transduction | Links Rho GTPase signaling to downstream effectors including MAPK and NF-κB pathways |
| Cell survival | Modulates apoptosis and cell survival pathways in response to cellular stress 3 |
| Associated Diseases | neurodegeneration |
| Interactions | ALS |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |