protein

TDP-43

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TDP-43: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2679Connections

30Hypotheses

27Analyses

50Outgoing

50Incoming

1Experiments

20Debates

Summary

TAR DNA-binding protein 43, an RNA/DNA-binding protein central to ALS, FTD, and AD pathology.

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🔬 Protein Info

Gene Symbol	TDP
Full Name	43 Protein
Aliases	TDP-43
Chromosome	1p36.
Function	TDP-43 is central to the pathogenesis of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and is commonly co-detected in Alzheimer's disease as a secondary pathology.
Subcellular Localization	signal (
GeneCards	TDP
Human Protein Atlas	TDP
FUS protein	another RNA-binding protein with similar pathogenic mechanisms in ALS and FTD
RNA metabolism pathways	particularly alternative
Associated Diseases	Ad, AD-TDP co-pathology, Aging, als
Known Drugs/Compounds	ASO, PROTAC, rapamycin, RAPAMYCIN, Rna Oligonucleotides, RNA oligonucleotides
Interactions	14-3-3θ, 4R-TAU, Actin, AGING, ALPHA-SYNUCLEIN, ALS
SciDEX Hypotheses	RNA-binding protein condensate maturation from rev Cell-state stratification is required to resolve B
KG Connections	1765 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🔮 Predicted Structure: TDP-43 — AlphaFold Q13148 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

TDP-43 Protein

redirect · 697 words

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Validated Hypothesis: Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 Proteinopathy Neuroinflammation in ALS/FTD

hypothesis · 5607 words

→

Validated Hypothesis: p38α Inhibitor and PRMT1 Activator Combination to Restore Physiological TDP-43 Phosphorylation-Methylation Balance

hypothesis · 4763 words

→

TDP-43 Proteinopathy

mechanism · 4112 words

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Validated Hypothesis: HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43 Liquid-Liquid Phase Separation

hypothesis · 3924 words

→

TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis

mechanism · 3471 words

→

Pathway Diagram

graph TD
    TDP_43["TDP-43"]
    TDP_43 -->|"activates"| mitochondrial_permeability_tra["mitochondrial permeability transition pore"]
    TDP_43 -->|"causes"| mitochondrial_DNA["mitochondrial DNA"]
    TDP_43 -->|"activates"| NF__B["NF-kappaB"]
    TDP_43 -->|"activates"| mPTP["mPTP"]
    TDP_43 -->|"causes"| ALS["ALS"]
    TDP_43 -.biomarker for.-> frontotemporal_lobar_degenerat["frontotemporal lobar degeneration"]
    TDP_43 -->|"expressed in"| neuron["neuron"]
    TDP_43 -->|"regulates"| translation_fidelity["translation fidelity"]
    ANXA11["ANXA11"] -->|"interacts"| TDP_43
    CSNK1D["CSNK1D"] -->|"phosphorylates"| TDP_43
    progranulin["progranulin"] -->|"regulates"| TDP_43
    ALS -->|"interacts"| TDP_43
    TARDBP["TARDBP"] -->|"encodes"| TDP_43
    APOE4["APOE4"] -->|"activates"| TDP_43
    GGGGCC_repeat_RNA["GGGGCC repeat RNA"] -->|"regulates"| TDP_43
    NEAT1["NEAT1"] -->|"regulates"| TDP_43
    C9orf72["C9orf72"] -->|"regulates"| TDP_43
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"] -->|"activates"| TDP_43

Outgoing (1333)

Target	Relation	Type	Str
oligomerization	regulates	process	1.00
RNA binding	regulates	process	1.00
LDLR	binds	gene	1.00
AGGREGATION	causes	process	1.00
SREBF2	binds	gene	1.00
STABILITY	regulates	process	1.00
HMGCR	binds	gene	1.00
HMGCS1	binds	gene	1.00
NEAT1	regulates	gene	0.95
Frontotemporal Lobar Degeneration	biomarker_for	disease	0.95
frontotemporal lobar degeneration	biomarker_for	disease	0.95
LC3ylation	regulates	process	0.95
Cryptic Splicing	regulates	process	0.95
Alzheimer'S Disease	associated_with	disease	0.95
RNA Splicing	involved_in	process	0.95
Rna Splicing	modulates	process	0.95
ALS-FTD	associated_with	disease	0.95
UNC13A	regulates	gene	0.95
Neurodegeneration	associated_with	process	0.95
Gene Expression	regulates	process	0.95
RNA Dysregulation	causes	process	0.95
Ad	associated_with	disease	0.95
Als	associated_with	disease	0.95
Mitochondrial DNA Release	associated_with	process	0.95
Frontotemporal Dementia	causes	disease	0.95
TDP-43 K181E	associated_with	biomarker	0.95
FTLD-TDP	associated_with	disease	0.95
Tdp-43 Proteinopathies	involved_in	disease	0.95
Alzheimer'S Disease	biomarker_for	disease	0.95
Aggregation	involved_in	process	0.95
Rna Splicing	involved_in	process	0.95
PKN1	regulates	gene	0.95
Ftld	associated_with	disease	0.95
UNC13A	inhibits	gene	0.95
Frontotemporal Lobar Degeneration	associated_with	disease	0.95
KCNQ2	regulates	gene	0.95
Cytoplasmic Aggregation	causes	phenotype	0.95
FTLD	associated_with	disease	0.95
Nuclear Condensation	involved_in	process	0.95
Alternative Splicing	regulates	process	0.95
UG-rich RNA sequences	binds	compound	0.95
ALS/FTLD	associated_with	disease	0.95
mRNA Splicing	regulates	process	0.95
Splicing Repression	regulates	process	0.95
Nuclear Depletion	causes	phenotype	0.95
Cryptic Exon Splicing	inhibits	process	0.95
Cryptic Exon Inclusion	inhibits	process	0.95
Cytoplasmatic Mislocalization	involved_in	phenotype	0.93
Mis-splicing	mediates	process	0.93
Amyotrophic Lateral Sclerosis	associated_with	disease	0.93

Incoming (1346)

Source	Relation	Type	Str
entities-histone-modifications	interacts_with	wiki	0.00
entities-mitochondrial-dynamics	interacts_with	wiki	0.00
p38α MAPK	phosphorylates	protein	1.00
TARDBP	associated_with	gene	1.00
SUMO2/3	conjugates	protein	1.00
FUS	interacts_with	gene	0.95
14-3-3θ	interacts_with	protein	0.95
TAU	interacts_with	protein	0.95
FRONTOTEMPORAL DEMENTIA	interacts_with	disease	0.95
ATXN2	suppresses	gene	0.95
STEM CELLS	activates	cell_type	0.95
MOTOR NEURONS	inhibits	cell_type	0.95
cAMP/PKA Signaling	regulates	pathway	0.95
TREM2	interacts_with	protein	0.95
NEURON	interacts_with	cell_type	0.95
Stress Granules	involved_in	cell_type	0.95
ASRGL1	regulates	gene	0.95
Stress	activates	phenotype	0.92
Loss Of Asrgl1	causes	mechanism	0.90
MAPK	phosphorylates	pathway	0.90
G4C2 Hexanucleotide Repeat Expansion	associated_with	mechanism	0.90
CK1D	phosphorylates	gene	0.90
ASRGL1	substrate_of	protein	0.90
TDP-43 Aggregates	associated_with	protein	0.90
ANXA11	associated_with	protein	0.90
RNA	interacts_with	gene	0.85
Oxidative Stress	activates	process	0.85
Hyperphosphorylation	modulates	process	0.85
Mistranslation	exacerbates	process	0.85
Cleavage	modulates	process	0.85
Rna Oligonucleotides	inhibits	compound	0.85
RNA oligonucleotides	targets	compound	0.85
Ubiquitination	modulates	process	0.85
Ubiquitin-Proteasome System	degrades	pathway	0.85
CHMP7	modulates	protein	0.85
ASRGL1	degrades	gene	0.85
ATAXIN-2	interacts_with	protein	0.85
microglial_activation	involved_in	mechanism	0.85
Phosphatidylserine	promotes	compound	0.85
TDP-43 Fibrils	phosphorylates	compound	0.85
RNA	regulates	gene	0.85
Cardiolipin	promotes	compound	0.85
NUFIP2	interacts_with	gene	0.85
SRRM2	interacts_with	gene	0.85
RNA	activates	gene	0.85
P38	associated_with	gene	0.80
ANXA11	interacts_with	gene	0.80
HNRNPC	regulates	gene	0.80
Cysteine Oxidation	associated_with	process	0.80
ASRGL1	interacts_with	protein	0.80

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
p38α Inhibitor and PRMT1 Activator Combination to Restore Ph	0.895	neurodegeneration	What is the therapeutic window between i
TDP-43 RNA-proteostasis failure across ALS, FTD, and AD/LATE	0.828	multi	Cross-disease neurodegeneration mechanis
Microglial AIM2 Inflammasome as the Primary Driver of TDP-43	0.824	neurodegeneration	What are the mechanisms by which gut mic
HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43	0.820	neurodegeneration	What is the therapeutic window between i
TIA1 Low-Complexity Domain Oxidation Drives Aberrant Stress	0.810	als	-

TDP-43 Proteinopathy as a Cross-Disease Pathological Substra	0.760	neurodegeneration	Cross-disease neurodegeneration mechanis
STMN2 Cryptic Exon Inclusion is the Earliest Loss-of-Functio	0.760	als	Causal Sequence of TDP-43 Nuclear Cleara
H3: G3BP1 as Nucleation Hub for TDP-43/FUS Seeding	0.743	neurodegeneration	How do pathological stress granules tran
TDP-43 condensation thermodynamics as a therapeutic target a	0.724	neuroscience	How can subcellular compartmentalization
C9orf72 ASO Treatment Reverses TDP-43 Pathology in ALS/FTD	0.720	neurodegeneration	Test Hypothesis Fixtures
SASP-Secreted MMP-9 from Senescent Microglia Generates Patho	0.718	als	What are the mechanisms by which microgl
TDP-43 Pathology Disrupts the HGS-PYGB Autophagy Receptor Ca	0.703	neurodegeneration	What mechanisms underlie neuronal resist
TDP-43 phase-separation and nuclear-function failure in ALS/	0.690	neurodegeneration	Test
STMN2 Restoration as a Prerequisite for Axon Growth After TD	0.683	neurodegeneration	What molecular mechanisms enable functio
Glial Neuroinflammatory Amplification by TDP-43 Pathology	0.680	neurodegeneration	What mechanisms underlie TDP-43's contri
Cyclophilin D (CypD) Displacement by Mitochondrial TDP-43	0.656	neurodegeneration	What upstream mechanisms cause TDP-43 to
ISR/eIF2α~P Overflow Represses Synaptic Proteostasis in Cort	0.650	frontotemporal-dementia	-
TDP-43 Liquid-Liquid Phase Separation Dominance in Stress Gr	0.650	alzheimers	-
RNA-binding protein condensate maturation from reversible ph	0.626	neurodegeneration	Causal Sequence of TDP-43 Nuclear Cleara
RNA-binding protein condensate maturation from reversible ph	0.626	neurodegeneration	Biophysical Determinants Shifting FUS/TD
Nuclear TDP-43 Depletion Drives Synaptic Splicing Dysregulat	0.620	neurodegeneration	Gap 006 analysis (archived stub)
Cell-state stratification is required to resolve Biophysical	0.612	neurodegeneration	Biophysical Determinants Shifting FUS/TD
Cell-state stratification is required to resolve Causal Sequ	0.612	neurodegeneration	Causal Sequence of TDP-43 Nuclear Cleara
Perturbation-first validation should precede therapeutic cla	0.608	neurodegeneration	Causal Sequence of TDP-43 Nuclear Cleara
Perturbation-first validation should precede therapeutic cla	0.608	neurodegeneration	Biophysical Determinants Shifting FUS/TD
TDP-43 LLPS and proteostasis dysregulation in ALS/FTD	0.600	neurodegeneration	Test
Cytosolic TDP-43 aggregation sequesters SNAP29 and syntaxin-	0.600	neurodegeneration	What are the neuron-specific effects of
Aβ42 oligomers drive TDP-43 phosphorylation at s409/410 thro	0.595	neurodegeneration	What mechanisms drive TDP-43 pathology s
Aβ-induced downregulation of circPDS5B derepresses TDP-43 mR	0.595	neurodegeneration	What mechanisms drive TDP-43 pathology s
Nuclear Export Deficits Increase Cytosolic TDP-43 Burden	0.580	neurodegeneration	What determines the specificity of TDP-4

Mentioning Analyses (27)

Scientific analyses that reference this entity

Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evalua

neurodegeneration | 2026-04-28 | 7 hypotheses Top: 0.662

Causal Sequence of TDP-43 Nuclear Clearance to Cytoplasmic Aggregation in ALS Mo

neurodegeneration | 2026-04-27 | 4 hypotheses Top: 0.760

Biophysical Determinants Shifting FUS/TDP-43 Phase Separation to Pathological Ag

neurodegeneration | 2026-04-27 | 4 hypotheses Top: 0.680

Oxidative Stress Upstream of TDP-43 Mislocalization in ALS Motor Neurons

neurodegeneration | 2026-04-27 | 0 hypotheses

How does the intron-retained RNA isoform mechanistically reduce glucocerebrosida

neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.645

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
MAPK pathway inhibition by QTJD through butyrate mechanism	exploratory	Mycoplasma pneumoniae pneumoni	0.900	0.00	Mouse macrophages	proposed	N/A

Related Papers (8)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861]	["Han X", "Sun S", "Sun Y", "Song Q", "Z	Autophagy	2020	1
Inhibition of autophagy in microglia and macrophages exacerbates innate immune r [PMID:36652438]	Hegdekar N, Sarkar C, Bustos S, Ritzel R	Autophagy	2023	0
Inflammasome assembly in neurodegenerative diseases. [PMID:37633753]	Singh J, Habean ML, Panicker N	Trends in neurosciences	2023	0
NLRP3/caspase-1/GSDMD-mediated pyroptosis exerts a crucial role in astrocyte pat [PMID:34877938]	Li S, Sun Y, Song M, Song Y, Fang Y, Zha	JCI insight	2021	0
Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodeg [PMID:30381407]	Gordon R, Albornoz EA, Christie DC, Lang	Science translational medicine	2018	0
A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-lin [PMID:21944779]	Unknown	Neuron	2011	0
TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease. [PMID:17469117]	Unknown	Annals of neurology	2007	0
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic latera [PMID:17023659]	Unknown	Science (New York, N.Y.)	2006	0

Debates (20)

Multi-agent debates referencing this entity

Structured research brief: Stathmin-2 Splice Switching to Prevent Axonal Degener

archived · Rounds: 2 · Score: 0.73 · 2026-04-28

Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evalua

closed · Rounds: 4 · Score: 0.76 · 2026-04-28

What are the biophysical determinants — RNA binding stoichiometry, post-translat

closed · Rounds: 4 · Score: 0.67 · 2026-04-28

What is the precise causal sequence of molecular events linking TDP-43 nuclear c

closed · Rounds: 4 · Score: 0.67 · 2026-04-28

Can targeting oxidative stress pathways (NRF2, SOD1, mitochondrial ROS) upstream

closed · Rounds: 6 · Score: 0.62 · 2026-04-27

Debate: Liquid-to-Solid Transition Pathology Reveals Granule Weak Points

closed · Rounds: 4 · Score: 0.58 · 2026-04-27

Hypothesis debate: Stathmin-2 Splice Switching to Prevent Axonal Degeneration Ac

closed · Rounds: 4 · Score: 0.49 · 2026-04-27

How does the intron-retained RNA isoform mechanistically reduce glucocerebrosida

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

How does lncRNA-0021 achieve sequence-specific binding to mmu-miR-6361 and what

closed · Rounds: 4 · Score: 0.66 · 2026-04-25

The study establishes G3BP1's role as a tunable switch for stress granule assemb

closed · Rounds: 4 · Score: 0.69 · 2026-04-22

Related Research

Hypotheses and analyses mentioning TDP-43 in their description or question text

TDP-43 Proteinopathy as a Cross-Disease Pathological Substrate

Score: 0.760 · neurodegeneration · 2026-04-28

TDP-43 misfolding and aggregation occurs as primary pathology in ALS/FTD (~95% and ~50% respectively) and as secondary p

STMN2 Cryptic Exon Inclusion is the Earliest Loss-of-Function Marker of TDP-43 N

Score: 0.760 · als · 2026-04-27

Loss of nuclear TDP-43 in ALS motor neurons first manifests as aberrant inclusion of the STMN2 cryptic exon 2a, producin

H3: G3BP1 as Nucleation Hub for TDP-43/FUS Seeding

Score: 0.743 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The molecular basis of G3BP1-mediated nucleation centers on the dynamic interplay

TDP-43 condensation thermodynamics as a therapeutic target and biomarker for nuc

Score: 0.724 · neuroscience · 2026-04-26

FRAP-based measurement of TDP-43 liquid-liquid phase separation state provides a continuous biomarker of nuclear-cytopla

C9orf72 ASO Treatment Reverses TDP-43 Pathology in ALS/FTD

Score: 0.720 · neurodegeneration · 2026-04-26

Antisense oligonucleotides targeting C9orf72 hexanucleotide repeat expansion reduce toxic DPR proteins and RNA foci, res

SASP-Secreted MMP-9 from Senescent Microglia Generates Pathological TDP-43 C-Ter

Score: 0.718 · als · 2026-04-26

The hypothesis proposes that MMP-9 (matrix metalloproteinase-9), secreted via the senescence-associated secretory phenot

TDP-43 Pathology Disrupts the HGS-PYGB Autophagy Receptor Cascade in Motor Neuro

Score: 0.703 · neurodegeneration · 2026-04-26

TDP-43 aggregates sequester hepatocyte growth factor-regulated tyrosine kinase substrate (HGS), a critical hub coordinat

TDP-43 phase-separation and nuclear-function failure in ALS/FTD

Score: 0.690 · neurodegeneration · 2026-04-30

Pathological TDP-43 condensate dynamics, phosphorylation, aggregation, and nuclear depletion disrupt RNA processing in A

STMN2 Restoration as a Prerequisite for Axon Growth After TDP-43 Clearance

Score: 0.683 · neurodegeneration · 2026-04-14

**Molecular Mechanism and Rationale** The molecular foundation of STMN2 restoration as a prerequisite for axonal regene

Glial Neuroinflammatory Amplification by TDP-43 Pathology

Score: 0.680 · neurodegeneration · 2026-04-21

## Mechanistic Overview Glial Neuroinflammatory Amplification by TDP-43 Pathology starts from the claim that modulating

Cyclophilin D (CypD) Displacement by Mitochondrial TDP-43

Score: 0.656 · neurodegeneration · 2026-04-21

## Mechanistic Overview Cyclophilin D (CypD) Displacement by Mitochondrial TDP-43 starts from the claim that modulating

RNA-binding protein condensate maturation from reversible phase separation to am

Score: 0.626 · neurodegeneration · 2026-04-28

RNA-binding protein condensate maturation from reversible phase separation to amyloid-like aggregation should produce a

RNA-binding protein condensate maturation from reversible phase separation to am

Score: 0.626 · neurodegeneration · 2026-04-28

RNA-binding protein condensate maturation from reversible phase separation to amyloid-like aggregation should produce a

TDP-43

Understanding Entity Pages

Summary

Wiki Pages (21)

TDP-43 Protein

Validated Hypothesis: Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 Proteinopathy Neuroinflammation in ALS/FTD

Validated Hypothesis: p38α Inhibitor and PRMT1 Activator Combination to Restore Physiological TDP-43 Phosphorylation-Methylation Balance

TDP-43 Proteinopathy

Validated Hypothesis: HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43 Liquid-Liquid Phase Separation

TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis

TARDBP Protein (TDP-43)

TAR DNA-Binding Protein 43 (TDP-43)

TDP-43 Protein

Update TDP-43 protein page with comprehensive content

Mechanism: Progranulin Loss and TDP-43 Pathology in FTD

Therapeutic Hypothesis: TDP-43 and a-synuclein pathologies in the amygdala...

VCP→TDP-43→ALS/FTD Causal Chain

AD-FTD Tau-TDP-43 Overlap: Mechanism Comparison

TDP-43 (TAR DNA-Binding Protein 43) - Biomarker

TDP-43 Pathology in Corticobasal Syndrome

TDP-43 Co-pathology in Corticobasal Syndrome

TDP-43 Causal Weight Analysis: Motor-Neuron Loss in ALS and FTD-TDP

Limbic-Predominant Age-Related TDP-43 Encephalopathy (LATE)

TDP-43 Proteinopathy in ALS

Molecular Glue for TDP-43 Aggregate Clearance

Pathway Diagram

Outgoing (1333)

Incoming (1346)

Targeting Hypotheses (30)

Mentioning Analyses (27)

Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evalua

Causal Sequence of TDP-43 Nuclear Clearance to Cytoplasmic Aggregation in ALS Mo

Biophysical Determinants Shifting FUS/TDP-43 Phase Separation to Pathological Ag

Oxidative Stress Upstream of TDP-43 Mislocalization in ALS Motor Neurons

How does the intron-retained RNA isoform mechanistically reduce glucocerebrosida

How does lncRNA-0021 achieve sequence-specific binding to mmu-miR-6361 and what

Is ferroptosis the primary driver of motor neuron death in ALS or an epiphenomen

Comparative epigenetic signatures across AD, PD, and ALS

What molecular mechanisms enable functional recovery and muscle re-innervation a

RNA binding protein dysregulation across ALS FTD AD

What are the specific design principles for small molecules that can selectively

What determines the selectivity and efficiency of intercellular transmission pat

What mechanisms underlie TDP-43's contribution to cognitive impairment severity

What upstream mechanisms cause TDP-43 to trigger mPTP opening and can this be th

What mechanisms underlie neuronal resistance to autophagy induction compared to

What mechanisms drive TDP-43 pathology specifically in Alzheimer's disease versu

How does chronic cGAS/STING activation downstream of TDP-43 contribute to progre

What determines the specificity of RNA-protein interactions that drive distinct

How does APOE4 mechanistically increase TDP-43 pathology frequency in Alzheimer'

What determines the specificity of TDP-43-induced mitochondrial DNA release for

How does TRIM21-mediated K63 ubiquitination of G3BP1 mechanistically inhibit liq

How do pathological stress granules transition from reversible to persistent in

How do disease-associated mutations in G3BP1 or its binding partners alter stres

RNA binding protein dysregulation across ALS FTD and AD

TDP-43 phase separation therapeutics for ALS-FTD

Protein aggregation cross-seeding across neurodegenerative diseases

RNA binding protein dysregulation across ALS FTD and AD

Experiments (1)

Related Papers (8)

Debates (20)

Structured research brief: Stathmin-2 Splice Switching to Prevent Axonal Degener

Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evalua

What are the biophysical determinants — RNA binding stoichiometry, post-translat

What is the precise causal sequence of molecular events linking TDP-43 nuclear c

Can targeting oxidative stress pathways (NRF2, SOD1, mitochondrial ROS) upstream

Debate: Liquid-to-Solid Transition Pathology Reveals Granule Weak Points

Hypothesis debate: Stathmin-2 Splice Switching to Prevent Axonal Degeneration Ac

How does the intron-retained RNA isoform mechanistically reduce glucocerebrosida

How does lncRNA-0021 achieve sequence-specific binding to mmu-miR-6361 and what

The study establishes G3BP1's role as a tunable switch for stress granule assemb

Related Research

TDP-43 Proteinopathy as a Cross-Disease Pathological Substrate

STMN2 Cryptic Exon Inclusion is the Earliest Loss-of-Function Marker of TDP-43 N

H3: G3BP1 as Nucleation Hub for TDP-43/FUS Seeding

TDP-43 condensation thermodynamics as a therapeutic target and biomarker for nuc

C9orf72 ASO Treatment Reverses TDP-43 Pathology in ALS/FTD

SASP-Secreted MMP-9 from Senescent Microglia Generates Pathological TDP-43 C-Ter

TDP-43 Pathology Disrupts the HGS-PYGB Autophagy Receptor Cascade in Motor Neuro

TDP-43 phase-separation and nuclear-function failure in ALS/FTD

STMN2 Restoration as a Prerequisite for Axon Growth After TDP-43 Clearance