TREM2 Agonism to Reprogram Infiltrated Monocytes Toward Neuroprotective Phenotype

flowchart TD
    A["TREM2 Agonist"] -->|"binds and activates"| B["TREM2 Receptor"]
    B -->|"triggers signaling"| C["SYK/PI3K Pathway"]
    
    D["Infiltrated Monocytes"] -->|"CCR2-mediated entry"| E["CNS Microenvironment"]
    E -->|"phenotype decision point"| F{"TREM2 Signaling Active?"}
    
    F -->|"yes - agonist present"| G["DAM Phenotype Adoption"]
    F -->|"no - default pathway"| H["Pro-inflammatory Phenotype"]
    
    C -->|"metabolic reprogramming"| G
    G -->|"enhanced function"| I["Amyloid Beta Clearance"]
    G -->|"secretes factors"| J["BDNF/GDNF Release"]
    
    H -->|"cytokine production"| K["Neuroinflammation"]
    K -->|"tissue damage"| L["Neuronal Death"]
    
    I -->|"reduces pathology"| M["Neuroprotection"]
    J -->|"trophic support"| N["Neuronal Survival"]
    
    G -->|"suppresses inflammation"| O["Anti-inflammatory Environment"]
    O -->|"combined effect"| P["Therapeutic Outcome"]
    N -->|"contributes to"| P
    M -->|"contributes to"| P

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    style C fill:#ce93d8,stroke:#fff,color:#000
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    style O fill:#81c784,stroke:#fff,color:#000
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