Scientific World Model

The world's most comprehensive mechanistic knowledge base for neurodegenerative diseases.

17,491 pages — genes, proteins, mechanisms, therapeutics, and more

What is the Scientific World Model?

Our AI agents have synthesized 17,000+ wiki-style pages covering every major entity, mechanism, and therapeutic avenue in neurodegeneration research. Each page is automatically generated and continuously updated from the latest scientific literature, connecting genes like APOE and MAPT to pathways, proteins, and disease mechanisms.

This forms a living knowledge graph that powers our hypothesis generation, therapeutic target identification, and research gap analysis. Browse by entity type below or search for any gene, protein, mechanism, or drug.

All (17,491)🧬 gene (3,869)🔬 cell (3,397)🔬 protein (3,107)⚙️ mechanism (1,789)💊 therapeutic (1,028)🏢 company (643)🏥 disease (496)🧪 clinical (392)🏛️ institution (308)👤 researcher (214)💡 idea (200)↪️ redirect (185)📊 biomarker (182)🧫 experiment (161) general (151)🔧 technology (151) ai_tool (141) entity (113)
Showing 1–50 of 708 pages matching "gene"

⚙️ Parthanatos in NeurodegenerationKG

mechanism · 6,619 words · 278 hyp52 ana55 exp

⚙️ GSK-3β in NeurodegenerationKG

mechanism · 5,020 words · 279 hyp52 ana57 exp

⚙️ Circadian Rhythm in NeurodegenerationKG

mechanism · 4,939 words · 283 hyp59 ana71 exp

⚙️ Energy Metabolism Dysfunction Comparison Across Neurodegenerative DiseasesKG

mechanism · 4,869 words · 34 hyp42 ana7 exp

⚙️ Blood-Brain Barrier Dysfunction in NeurodegenerationKG

mechanism · 4,726 words · 331 hyp66 ana62 exp

⚙️ Neurotrophin Signaling Pathways in NeurodegenerationKG

mechanism · 4,695 words · 286 hyp57 ana57 exp

⚙️ Wnt Non-Canonical Signaling Pathways in NeurodegenerationKG

mechanism · 4,664 words · 293 hyp56 ana57 exp

⚙️ Mitophagy Pathway in NeurodegenerationKG

mechanism · 4,637 words · 300 hyp61 ana65 exp

⚙️ TREM2 Microglial Signaling Pathway in NeurodegenerationKG

mechanism · 4,613 words · 301 hyp66 ana95 exp

⚙️ Axonal Transport Dysfunction Comparison Across Neurodegenerative DiseasesKG

mechanism · 4,604 words · 36 hyp48 ana13 exp

⚙️ AI and Machine Learning in NeurodegenerationKG

mechanism · 4,541 words · 288 hyp57 ana58 exp

⚙️ Vitamin D Signaling Pathway in NeurodegenerationKG

mechanism · 4,520 words · 291 hyp57 ana57 exp

⚙️ VEGF/Angiogenesis Pathway in NeurodegenerationKG

mechanism · 4,480 words · 284 hyp53 ana60 exp

⚙️ Epigenetic Dysregulation in NeurodegenerationKG

mechanism · 4,376 words · 312 hyp62 ana79 exp

⚙️ Mitochondrial Dysfunction in NeurodegenerationKG

mechanism · 4,363 words · 291 hyp59 ana62 exp

⚙️ Epigenetic Dysregulation Comparison -- AD/PD/ALS/FTD/HDKG

mechanism · 4,361 words · 45 hyp46 ana49 exp

⚙️ Epigenetic Alterations in Alzheimer's DiseaseKG

mechanism · 4,331 words · 144 hyp71 ana78 exp

⚙️ Pre-symptomatic Conversion Windows in ALS Genetic Risk CarriersKG

mechanism · 4,322 words · 26 hyp43 ana27 exp

⚙️ Copper Dyshomeostasis in NeurodegenerationKG

mechanism · 4,255 words · 279 hyp52 ana54 exp

⚙️ Splice-Modulating Therapies for NeurodegenerationKG

mechanism · 4,197 words · 290 hyp58 ana69 exp

⚙️ Traumatic Brain Injury and Neurodegeneration PathwayKG

mechanism · 4,171 words · 297 hyp66 ana63 exp

⚙️ CREB Signaling in NeurodegenerationKG

mechanism · 4,156 words · 296 hyp60 ana57 exp

⚙️ Excitotoxicity in NeurodegenerationKG

mechanism · 4,129 words · 289 hyp55 ana55 exp

⚙️ Gene-Mechanism-Therapy Causal ChainsKG

mechanism · 4,075 words · 94 hyp52 ana22 exp

⚙️ Protein Aggregation Comparison in NeurodegenerationKG

mechanism · 4,048 words · 286 hyp53 ana68 exp

⚙️ Non-Homologous End Joining in NeurodegenerationKG

mechanism · 3,995 words · 279 hyp56 ana54 exp

⚙️ IGF-1 Signaling Pathway in NeurodegenerationKG

mechanism · 3,993 words · 291 hyp53 ana61 exp

⚙️ Nanobody Therapy for Neurodegenerative DiseasesKG

mechanism · 3,966 words · 50 hyp51 ana1 exp

⚙️ Microglial Senescence Pathway in NeurodegenerationKG

mechanism · 3,902 words · 297 hyp55 ana61 exp

⚙️ Peroxisome Pathway in NeurodegenerationKG

mechanism · 3,885 words · 282 hyp56 ana59 exp

⚙️ Thyroid Hormone Signaling Pathway in NeurodegenerationKG

mechanism · 3,884 words · 291 hyp57 ana65 exp

⚙️ Gut-Brain Axis in NeurodegenerationKG

mechanism · 3,881 words · 283 hyp61 ana61 exp

⚙️ metabolic-dysfunction-neurodegenerationKG

mechanism · 3,868 words · 291 hyp60 ana58 exp

⚙️ Cellular Reprogramming Therapies for NeurodegenerationKG

mechanism · 3,858 words · 282 hyp59 ana55 exp

⚙️ Lipid Peroxidation in NeurodegenerationKG

mechanism · 3,848 words · 285 hyp55 ana70 exp

⚙️ Autophagy-Lysosomal Impairment Across Neurodegenerative DiseasesKG

mechanism · 3,847 words · 29 hyp45 ana18 exp

⚙️ Synaptic Dysfunction in NeurodegenerationKG

mechanism · 3,810 words · 299 hyp60 ana64 exp

⚙️ Notch Signaling Pathway in NeurodegenerationKG

mechanism · 3,799 words · 298 hyp54 ana56 exp

⚙️ NF-kB Signaling Pathway in NeurodegenerationKG

mechanism · 3,782 words · 293 hyp53 ana63 exp

⚙️ Pannexin 1 and P2X7 Receptor Signaling in NeurodegenerationKG

mechanism · 3,756 words · 294 hyp54 ana57 exp

⚙️ Cellular Senescence in NeurodegenerationKG

mechanism · 3,734 words · 284 hyp55 ana57 exp

⚙️ Transcriptional Regulation in NeurodegenerationKG

mechanism · 3,716 words · 286 hyp54 ana70 exp

⚙️ Metal Homeostasis Dysfunction Comparison Across Neurodegenerative DiseasesKG

mechanism · 3,711 words · 15 hyp41 ana5 exp

⚙️ Quinolinic Acid Neurotoxicity in NeurodegenerationKG

mechanism · 3,699 words · 280 hyp52 ana65 exp

⚙️ er-stress-neurodegenerationKG

mechanism · 3,696 words · 283 hyp57 ana54 exp

⚙️ NF-κB Signaling Pathway in NeurodegenerationKG

mechanism · 3,689 words · 292 hyp57 ana62 exp

⚙️ Calcium Signaling Dysregulation in NeurodegenerationKG

mechanism · 3,676 words · 313 hyp60 ana54 exp

⚙️ Psychobiotic Therapy for Neurodegenerative DiseasesKG

mechanism · 3,674 words · 168 hyp64 ana8 exp

⚙️ Chaperone-Mediated Autophagy in NeurodegenerationKG

mechanism · 3,671 words · 292 hyp54 ana55 exp

⚙️ CNTF Signaling Pathway in NeurodegenerationKG

mechanism · 3,667 words · 291 hyp57 ana54 exp

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