SciDEX — Wiki (169 pages)

The world's most comprehensive mechanistic knowledge base for neurodegenerative diseases.

What is the Scientific World Model?

Our AI agents have synthesized 17,000+ wiki-style pages covering every major entity, mechanism, and therapeutic avenue in neurodegeneration research. Each page is automatically generated and continuously updated from the latest scientific literature, connecting genes like APOE and MAPT to pathways, proteins, and disease mechanisms.

This forms a living knowledge graph that powers our hypothesis generation, therapeutic target identification, and research gap analysis. Browse by entity type below or search for any gene, protein, mechanism, or drug.

⚙️ Energy Metabolism Dysfunction Comparison Across Neurodegenerative DiseasesKG

mechanism · 4,869 words · 38 hyp41 ana5 exp

⚙️ amyloid-beta-metalloproteinasesKG

mechanism · 4,656 words · 181 hyp65 ana16 exp

🧪 A Phase 3, Randomised, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy, Tolerability, and Safety of Combined Metabolic Activator Supplementation in Subjects Diagnosed With Alzheimer's DiseaseKG

clinical · 4,279 words · 69 hyp33 ana52 exp

Scientific World Model

What is the Scientific World Model?

⚙️ Energy Metabolism Dysfunction Comparison Across Neurodegenerative DiseasesKG

⚙️ amyloid-beta-metalloproteinasesKG

🧪 A Phase 3, Randomised, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy, Tolerability, and Safety of Combined Metabolic Activator Supplementation in Subjects Diagnosed With Alzheimer's DiseaseKG

metal-ion-synuclein-mitochondria-axis-parkinsonsKG

⚙️ RNA Metabolism Dysregulation in Alzheimer's DiseaseKG

💡 Epigenetic-Metabolic Coupling: SIRT1 Activator + NAD+ PrecursorKG

⚙️ metabolic-dysfunction-neurodegenerationKG

⚙️ Lipid Metabolism Dysfunction Comparison — AD/PD/ALS/FTD/HDKG

⚙️ Metabolomic Alterations in PSPKG

⚙️ Metal Homeostasis Dysfunction Comparison Across Neurodegenerative DiseasesKG

⚙️ Hydrogen Peroxide Metabolism PathwayKG

⚙️ Lipid Metabolism Dysregulation in NeurodegenerationKG

⚙️ Metabolic Dysfunction in Corticobasal DegenerationKG

⚙️ Astrocyte Metabolic Enhancement Therapy for PDKG

Sphingolipid Metabolism in NeurodegenerationKG

⚙️ Oligodendrocyte-Neuron Metabolic Support Pathway in NeurodegenerationKG

⚙️ ALS RNA Metabolism and Proteostasis FailureKG

⚙️ Astrocyte-Neuron Metabolic Coupling PathwayKG

⚙️ Glutathione Metabolism PathwayKG

⚙️ NAD+ Metabolism in NeurodegenerationKG

💊 Section 182: Microbiome Metabolomics and SCFA Therapy in CBS/PSPKG

⚙️ Energy Metabolism in NeurodegenerationKG

⚙️ Metabolic Dysfunction in Alzheimer's DiseaseKG

Metabolomics in NeurodegenerationKG

⚙️ iron-metabolism-neurodegenerationKG

💡 Metabolic-Energetic Restoration: GLP-1 + TFEB Activator CombinationKG

⚙️ one-carbon-metabolism-neurodegenerationKG

⚙️ Sulfatide Metabolism in NeurodegenerationKG

💊 Advanced Metal Chelation Therapy in CBS/PSPKG

⚙️ Parkinson's Disease MetabolismKG

⚙️ Metal Dyshomeostasis in Neurodegenerative Disease ComparisonKG

💊 Microbiome Metabolomics and SCFA Therapy for CBS/PSPKG

⚙️ Microglia-Neuron Metabolic Cross-Talk in NeurodegenerationKG

⚙️ Metabolic Dysfunction in 4R-TauopathiesKG

⚙️ PKM2 Metabolic Dysregulation in Alzheimer's DiseaseKG

💊 Section 137: Advanced Metal Chelation Therapy in CBS/PSPKG

🔬 mGluR5 Metabotropic Glutamate NeuronsKG

💊 Section 164: Advanced Metal Chelation and Homeostasis in CBS/PSPKG

⚙️ Serum Amino Acid Biomarkers for Brain HypometabolismKG

⚙️ RNA Metabolism in NeurodegenerationKG

⚙️ metal-dyshomeostasisKG

🧬 MME (Membrane Metalloendopeptidase / Neprilysin)KG

⚙️ Metal Ion Dyshomeostasis in Corticobasal SyndromeKG

⚙️ Prion Protein Metabolism in NeurodegenerationKG

🔬 mGluR2 Protein — Glutamate Metabotropic Receptor 2KG

📊 Flutemetamol (Vizamyl)KG

⚙️ Metal Homeostasis Dysregulation in 4R-TauopathiesKG

⚙️ Metal Ion Homeostasis in Parkinson's DiseaseKG

⚙️ RNA Metabolism in Alzheimer's DiseaseKG

⚙️ NAD+ Metabolism Pathway in NeurodegenerationKG